Human Gene Control by Vital Oncogenes: Revisiting a Theoretical Model and Its Implications for Targeted Cancer Therapy
Abstract
:1. Introduction
2. Gene Control by Phosphoproteins: A Basic Theory
- Nuclear proto-oncogene protein kinases are activated by phosphorylation.
- These phosphorylated activated protein kinases bind to recognition sites in the major groove of the DNA helix as it winds around the nucleosome core histones.
- A series of phosphorylation reactions mediated by these nuclear phosphoproteins and facilitated by histone H1 phosphorylation result in the displacement of histone H1 away from the site of gene activation eventually allowing access by the transcription initiation complex.
- The exposed DNA sequences are essentially promoter sites.
- The phosphorylation reaction cascade includes recruitment and phosphorylation of either DNA polymerase or RNA polymerase.
- The intact histone octamer that makes up the nucleosome core complex functions as a scaffold during gene activity. The model assigned a central role to nuclear phosphoproteins.
3. The Role of Cyclin-Dependent Kinases and the pRB Protein in Cell Cycle Control
4. Genomic Structure and Epigenetic Regulation
5. c-Myc a Prototype Vital Oncogene
6. Conclusion
Supplementary Material
ijms-13-00316-s001.pdfReferences
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Willis, R.E. Human Gene Control by Vital Oncogenes: Revisiting a Theoretical Model and Its Implications for Targeted Cancer Therapy. Int. J. Mol. Sci. 2012, 13, 316-335. https://doi.org/10.3390/ijms13010316
Willis RE. Human Gene Control by Vital Oncogenes: Revisiting a Theoretical Model and Its Implications for Targeted Cancer Therapy. International Journal of Molecular Sciences. 2012; 13(1):316-335. https://doi.org/10.3390/ijms13010316
Chicago/Turabian StyleWillis, Rudolph E. 2012. "Human Gene Control by Vital Oncogenes: Revisiting a Theoretical Model and Its Implications for Targeted Cancer Therapy" International Journal of Molecular Sciences 13, no. 1: 316-335. https://doi.org/10.3390/ijms13010316