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The Important Molecular Markers on Chromosome 17 and Their Clinical Impact in Breast Cancer
Department of Surgery, School of Medicine, The Ninth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200011, China
Department of Surgery, School of Medicine, Shanghai Ruijin Hospital of Shanghai Jiao Tong University, Shanghai 200025, China
* Author to whom correspondence should be addressed.
Received: 13 July 2011; in revised form: 16 August 2011 / Accepted: 31 August 2011 / Published: 5 September 2011
Abstract: Abnormalities of chromosome 17 are important molecular genetic events in human breast cancers. Several famous oncogenes (HER2, TOP2A and TAU), tumor suppressor genes (p53, BRCA1 and HIC-1) or DNA double-strand break repair gene (RDM1) are located on chromosome 17. We searched the literature on HER2, TOP2A, TAU, RDM1, p53, BRCA1 and HIC-1 on the Pubmed database. The association of genes with chromosome 17, biological functions and potential significance are reviewed. In breast cancer, the polysomy 17 (three or more) is the predominant numerical aberration. HER2 amplification is widely utilized as molecular markers for trastuzumab target treatment. Amplified TOP2A, TAU and RDM1 genes are related to a significant response to anthracycline-based chemotherapy, taxane or cisplatin, respectively. In contrast, p53, BRCA1 and HIC-1 are important tumor suppressor genes related to breast carcinogenesis. This review focused on several crucial molecular markers residing on chromosome 17. The authors consider the somatic aberrations of chromosome 17 and associated genes in breast cancer.
Keywords: chromosome 17; biomarkers; breast cancer
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Cite This Article
MDPI and ACS Style
Zhang, W.; Yu, Y. The Important Molecular Markers on Chromosome 17 and Their Clinical Impact in Breast Cancer. Int. J. Mol. Sci. 2011, 12, 5672-5683.
Zhang W, Yu Y. The Important Molecular Markers on Chromosome 17 and Their Clinical Impact in Breast Cancer. International Journal of Molecular Sciences. 2011; 12(9):5672-5683.
Zhang, Wei; Yu, Yingyan. 2011. "The Important Molecular Markers on Chromosome 17 and Their Clinical Impact in Breast Cancer." Int. J. Mol. Sci. 12, no. 9: 5672-5683.