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Int. J. Mol. Sci. 2011, 12(8), 4964-4974; doi:10.3390/ijms12084964

Interaction of Human Serum Album and C60 Aggregates in Solution

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 10085, China
* Author to whom correspondence should be addressed.
Received: 30 March 2011 / Revised: 12 July 2011 / Accepted: 27 July 2011 / Published: 4 August 2011
(This article belongs to the Special Issue Bioactive Nanoparticles (special issue))
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An important property of C60 in aquatic ecotoxicology is that it can form stable aggregates with nanoscale dimensions, namely nC60. Aggregation allows fullerenes to remain suspended for a long time, and the reactivity of individual C60 is substantially altered in this aggregate form. Herein, we investigated the interaction of nC60 and human serum album (HSA) using the methods of fluorescence, fluorescence dynamics, circular dichroism (CD), and site marker competitive experiments. We proposed a binding model consistent with the available experimental results for the interactions of nC60 with HSA. During the interaction process, the structure and conformation of HSA were affected, leading to functional changes of drug binding sites of HSA.
Keywords: nC60; HSA; interaction; protein; fluorescence nC60; HSA; interaction; protein; fluorescence
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Song, M.; Liu, S.; Yin, J.; Wang, H. Interaction of Human Serum Album and C60 Aggregates in Solution. Int. J. Mol. Sci. 2011, 12, 4964-4974.

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