Int. J. Mol. Sci. 2011, 12(8), 4861-4871; doi:10.3390/ijms12084861
Article

Silibinin Causes Apoptosis and Cell Cycle Arrest in Some Human Pancreatic Cancer Cells

Received: 24 May 2011; in revised form: 5 July 2011 / Accepted: 20 July 2011 / Published: 2 August 2011
(This article belongs to the Section Bioactives and Nutraceuticals)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Silibinin, an effective anti-cancer and chemopreventive agent in various epithelial cancer models, has been reported to inhibit cancer cell growth through mitogenic signaling pathways. However, whether it can inhibit human pancreatic carcinoma growth and what are the underlying mechanisms is still not well elucidated. Here, we evaluated the inhibitory proliferation effects of Silibinin in pancreatic carcinoma growth and examined whether Silibinin modulates cell cycle and apoptosis. Our results indicate that Silibinin effectively inhibited the pancreatic carcinoma AsPC-1, BxPC-3 and Panc-1 cells’ proliferation and caused apoptosis. Silibinin induced a decrease in S phase and cell cycle arrest in G1 phase in AsPC-1 cells, but had no obvious changes in BxPC-3 and Panc-1 cell cycle. Furthermore, these results suggest that Silibinin might be a candidate chemopreventive agent for pancreatic carcinoma therapy.
Keywords: Silibinin; cell proliferation; apoptosis; cell-cycle arrest; pancreatic cancer
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MDPI and ACS Style

Ge, Y.; Zhang, Y.; Chen, Y.; Li, Q.; Chen, J.; Dong, Y.; Shi, W. Silibinin Causes Apoptosis and Cell Cycle Arrest in Some Human Pancreatic Cancer Cells. Int. J. Mol. Sci. 2011, 12, 4861-4871.

AMA Style

Ge Y, Zhang Y, Chen Y, Li Q, Chen J, Dong Y, Shi W. Silibinin Causes Apoptosis and Cell Cycle Arrest in Some Human Pancreatic Cancer Cells. International Journal of Molecular Sciences. 2011; 12(8):4861-4871.

Chicago/Turabian Style

Ge, Yakun; Zhang, Yuanxin; Chen, Yunpeng; Li, Quanshun; Chen, Jun; Dong, Ying; Shi, Wei. 2011. "Silibinin Causes Apoptosis and Cell Cycle Arrest in Some Human Pancreatic Cancer Cells." Int. J. Mol. Sci. 12, no. 8: 4861-4871.

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