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Silibinin Causes Apoptosis and Cell Cycle Arrest in Some Human Pancreatic Cancer Cells
Key Laboratory for Molecular Enzymology & Engineering of the Ministry of Education, School of Life Science, Jilin University, Changchun 130023, China
College of Environmental & Biological Engineering, Jilin Institute of Chemical Technology, Jilin 132022, China
The Center for Combinatorial Chemistry and Drug Discovery, the College of Pharmacy, Jilin University, Changchun 130021, China
School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China
* Author to whom correspondence should be addressed.
Received: 24 May 2011; in revised form: 5 July 2011 / Accepted: 20 July 2011 / Published: 2 August 2011
Abstract: Silibinin, an effective anti-cancer and chemopreventive agent in various epithelial cancer models, has been reported to inhibit cancer cell growth through mitogenic signaling pathways. However, whether it can inhibit human pancreatic carcinoma growth and what are the underlying mechanisms is still not well elucidated. Here, we evaluated the inhibitory proliferation effects of Silibinin in pancreatic carcinoma growth and examined whether Silibinin modulates cell cycle and apoptosis. Our results indicate that Silibinin effectively inhibited the pancreatic carcinoma AsPC-1, BxPC-3 and Panc-1 cells’ proliferation and caused apoptosis. Silibinin induced a decrease in S phase and cell cycle arrest in G1 phase in AsPC-1 cells, but had no obvious changes in BxPC-3 and Panc-1 cell cycle. Furthermore, these results suggest that Silibinin might be a candidate chemopreventive agent for pancreatic carcinoma therapy.
Keywords: Silibinin; cell proliferation; apoptosis; cell-cycle arrest; pancreatic cancer
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MDPI and ACS Style
Ge, Y.; Zhang, Y.; Chen, Y.; Li, Q.; Chen, J.; Dong, Y.; Shi, W. Silibinin Causes Apoptosis and Cell Cycle Arrest in Some Human Pancreatic Cancer Cells. Int. J. Mol. Sci. 2011, 12, 4861-4871.
Ge Y, Zhang Y, Chen Y, Li Q, Chen J, Dong Y, Shi W. Silibinin Causes Apoptosis and Cell Cycle Arrest in Some Human Pancreatic Cancer Cells. International Journal of Molecular Sciences. 2011; 12(8):4861-4871.
Ge, Yakun; Zhang, Yuanxin; Chen, Yunpeng; Li, Quanshun; Chen, Jun; Dong, Ying; Shi, Wei. 2011. "Silibinin Causes Apoptosis and Cell Cycle Arrest in Some Human Pancreatic Cancer Cells." Int. J. Mol. Sci. 12, no. 8: 4861-4871.