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Microfluidic Technologies for Synthetic Biology
School of Nano-Bioscience and Chemical Engineering, Ulsan National Institute of Science and Technology, 100 Banyeon-ri, Ulsan 689–798, Korea
School of Mechanical and Advanced Materials Engineering, Ulsan National Institute of Science and Technology, 100 Banyeon-ri, Ulsan 689–798, Korea
* Authors to whom correspondence should be addressed.
Received: 7 April 2011; in revised form: 20 May 2011 / Accepted: 26 May 2011 / Published: 3 June 2011
Abstract: Microfluidic technologies have shown powerful abilities for reducing cost, time, and labor, and at the same time, for increasing accuracy, throughput, and performance in the analysis of biological and biochemical samples compared with the conventional, macroscale instruments. Synthetic biology is an emerging field of biology and has drawn much attraction due to its potential to create novel, functional biological parts and systems for special purposes. Since it is believed that the development of synthetic biology can be accelerated through the use of microfluidic technology, in this review work we focus our discussion on the latest microfluidic technologies that can provide unprecedented means in synthetic biology for dynamic profiling of gene expression/regulation with high resolution, highly sensitive on-chip and off-chip detection of metabolites, and whole-cell analysis.
Keywords: microfluidics; synthetic biology; genetic circuits; gene expression and regulation; metabolite detection; whole-cell analysis
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MDPI and ACS Style
Vinuselvi, P.; Park, S.; Kim, M.; Park, J.M.; Kim, T.; Lee, S.K. Microfluidic Technologies for Synthetic Biology. Int. J. Mol. Sci. 2011, 12, 3576-3593.
Vinuselvi P, Park S, Kim M, Park JM, Kim T, Lee SK. Microfluidic Technologies for Synthetic Biology. International Journal of Molecular Sciences. 2011; 12(6):3576-3593.
Vinuselvi, Parisutham; Park, Seongyong; Kim, Minseok; Park, Jung Min; Kim, Taesung; Lee, Sung Kuk. 2011. "Microfluidic Technologies for Synthetic Biology." Int. J. Mol. Sci. 12, no. 6: 3576-3593.