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Int. J. Mol. Sci. 2011, 12(5), 3237-3249; doi:10.3390/ijms12053237
Communication

Mechanism of Sphingosine 1-Phosphate- and Lysophosphatidic Acid-Induced Up-Regulation of Adhesion Molecules and Eosinophil Chemoattractant in Nerve Cells

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Received: 8 March 2011; in revised form: 5 May 2011 / Accepted: 9 May 2011 / Published: 17 May 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: The lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) act via G-protein coupled receptors S1P1–5 and LPA1–3 respectively, and are implicated in allergy. Eosinophils accumulate at innervating cholinergic nerves in asthma and adhere to nerve cells via intercellular adhesion molecule-1 (ICAM-1). IMR-32 neuroblastoma cells were used as an in vitro cholinergic nerve cell model. The Gi coupled receptors S1P1, S1P3, LPA1, LPA2 and LPA3 were expressed on IMR-32 cells. Both S1P and LPA induced ERK phosphorylation and ERK- and Gi-dependent up-regulation of ICAM-1 expression, with differing time courses. LPA also induced ERK- and Gi-dependent up-regulation of the eosinophil chemoattractant, CCL-26. The eosinophil granule protein eosinophil peroxidase (EPO) induced ERK-dependent up-regulation of transcription of S1P1, LPA1, LPA2 and LPA3, providing the situation whereby eosinophil granule proteins may enhance S1P- and/or LPA- induced eosinophil accumulation at nerve cells in allergic conditions.
Keywords: lysophospholipid; neuronal; eosinophil lysophospholipid; neuronal; eosinophil
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Costello, R.W.; Maloney, M.; Atiyeh, M.; Gleich, G.; Walsh, M.-T. Mechanism of Sphingosine 1-Phosphate- and Lysophosphatidic Acid-Induced Up-Regulation of Adhesion Molecules and Eosinophil Chemoattractant in Nerve Cells. Int. J. Mol. Sci. 2011, 12, 3237-3249.

AMA Style

Costello RW, Maloney M, Atiyeh M, Gleich G, Walsh M-T. Mechanism of Sphingosine 1-Phosphate- and Lysophosphatidic Acid-Induced Up-Regulation of Adhesion Molecules and Eosinophil Chemoattractant in Nerve Cells. International Journal of Molecular Sciences. 2011; 12(5):3237-3249.

Chicago/Turabian Style

Costello, Richard W.; Maloney, Michael; Atiyeh, Mazin; Gleich, Gerald; Walsh, Marie-Therese. 2011. "Mechanism of Sphingosine 1-Phosphate- and Lysophosphatidic Acid-Induced Up-Regulation of Adhesion Molecules and Eosinophil Chemoattractant in Nerve Cells." Int. J. Mol. Sci. 12, no. 5: 3237-3249.



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