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Antioxidant Properties of Aminoethylcysteine Ketimine Decarboxylated Dimer: A Review
Department of Biochemical Sciences, Sapienza, University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy
Department of Chemistry and Technology of Drugs Sapienza, University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy
National Research Institute on Food and Nutrition Via Ardeatina, 546, 00178 Rome, Italy
* Author to whom correspondence should be addressed.
Received: 1 March 2011; in revised form: 25 April 2011 / Accepted: 29 April 2011 / Published: 12 May 2011
Abstract: Aminoethylcysteine ketimine decarboxylated dimer is a natural sulfur-containing compound detected in human plasma and urine, in mammalian brain and in many common edible vegetables. Over the past decade many studies have been undertaken to identify its metabolic role. Attention has been focused on its antioxidant properties and on its reactivity against oxygen and nitrogen reactive species. These properties have been studied in different model systems starting from plasma lipoproteins to specific cellular lines. All these studies report that aminoethylcysteine ketimine decarboxylated dimer is able to interact both with reactive oxygen and nitrogen species (hydrogen peroxide, superoxide anion, hydroxyl radical, peroxynitrite and its derivatives). Its antioxidant activity is similar to that of Vitamin E while higher than other hydrophilic antioxidants, such as trolox and N-acetylcysteine.
Keywords: sulfur-containing antioxidants; aminoethylcysteine ketimine decarboxylated dimer; reactive oxygen species; reactive nitrogen species
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MDPI and ACS Style
Macone, A.; Fontana, M.; Barba, M.; Botta, B.; Nardini, M.; Ghirga, F.; Calcaterra, A.; Pecci, L.; Matarese, R.M. Antioxidant Properties of Aminoethylcysteine Ketimine Decarboxylated Dimer: A Review. Int. J. Mol. Sci. 2011, 12, 3072-3084.
Macone A, Fontana M, Barba M, Botta B, Nardini M, Ghirga F, Calcaterra A, Pecci L, Matarese RM. Antioxidant Properties of Aminoethylcysteine Ketimine Decarboxylated Dimer: A Review. International Journal of Molecular Sciences. 2011; 12(5):3072-3084.
Macone, Alberto; Fontana, Mario; Barba, Marco; Botta, Bruno; Nardini, Mirella; Ghirga, Francesca; Calcaterra, Andrea; Pecci, Laura; Matarese, Rosa Marina. 2011. "Antioxidant Properties of Aminoethylcysteine Ketimine Decarboxylated Dimer: A Review." Int. J. Mol. Sci. 12, no. 5: 3072-3084.