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Int. J. Mol. Sci. 2011, 12(5), 3006-3017; doi:10.3390/ijms12053006
Article

Optimization of Ultrasound-Assisted Extraction of Anthocyanins from Mulberry, Using Response Surface Methodology

1
, 1
, 1
 and 1,2,*
Received: 27 February 2011; in revised form: 6 April 2011 / Accepted: 20 April 2011 / Published: 10 May 2011
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: Mulberry is one of the most widely used traditional Chinese medicines. Anthocyanins are the main bioactive components of mulberry, and possess important biological activities, such as antimicrobial, anti-inflammatory and antioxidant activities. This study investigated the ultrasound-assisted extraction (UAE) of anthocyanins from mulberry by using response surface methodology (RSM). The extraction conditions associated with anthocyanin yield, including extraction solvent, liquid-to-solid rate, temperature and extraction time, are discussed. The optimal conditions obtained by RSM for UAE from mulberry include 63.8% methanol contains 1% (v/v) trifluoroacetic acid (TFA), 43.2 °C temperature, 23.8 (v/w) liquid-to-solid ratio, and 40 min time for the maximum yield (64.70 ± 0.45 mg/g). The results indicated that the UAE can be an effective method for the extraction of some active components from plant materials.
Keywords: ultrasound-assisted extraction; anthocyanins; mulberry; response surface methodology ultrasound-assisted extraction; anthocyanins; mulberry; response surface methodology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zou, T.-B.; Wang, M.; Gan, R.-Y.; Ling, W.-H. Optimization of Ultrasound-Assisted Extraction of Anthocyanins from Mulberry, Using Response Surface Methodology. Int. J. Mol. Sci. 2011, 12, 3006-3017.

AMA Style

Zou T-B, Wang M, Gan R-Y, Ling W-H. Optimization of Ultrasound-Assisted Extraction of Anthocyanins from Mulberry, Using Response Surface Methodology. International Journal of Molecular Sciences. 2011; 12(5):3006-3017.

Chicago/Turabian Style

Zou, Tang-Bin; Wang, Min; Gan, Ren-You; Ling, Wen-Hua. 2011. "Optimization of Ultrasound-Assisted Extraction of Anthocyanins from Mulberry, Using Response Surface Methodology." Int. J. Mol. Sci. 12, no. 5: 3006-3017.


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