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Int. J. Mol. Sci. 2011, 12(4), 2383-2394; doi:10.3390/ijms12042383

Effect of 2-Hydroxypropyl-β-cyclodextrin on Solubility of Sparingly Soluble Drug Derivatives of Anthranilic Acid

Department of Physical Chemistry, Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland
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Received: 10 March 2011 / Revised: 30 March 2011 / Accepted: 2 April 2011 / Published: 6 April 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Guest-host complex formation of three drug derivatives of anthranilic acid, mefenamic acid, niflumic acid, and flufenamic acid with 2-hydroxypropyl-β-cyclodextrin (2HP-β-CD) in aqueous solutions was investigated using “Phase solubility study” with UV-vis spectrophotometry. Solubility of sparingly soluble drugs has been improved by addition of 2HP-β-CD at two temperatures 298.15 K and 310.15 K and two pH values 2 and 7. The influence of different 2HP-β-CD concentration on solubility of drugs at different pH and temperatures has been investigated. The 2HP-β-CD-drug complex stability constants (Ks), and dissociations constants (Kd), as well as the thermodynamic parameters of reaction, i.e., the free energy change (ΔG), the enthalpy change (ΔH) and the entropy change (ΔS), were determined. The experimental data indicated formation of 1:1 inclusion complexes, which were found effective binders increasing the solubility of drugs.
Keywords: experimental solubility; 2-hydroxypropyl-β-cyclodextrin; solubility enhancement; thermodynamics of complex formation   experimental solubility; 2-hydroxypropyl-β-cyclodextrin; solubility enhancement; thermodynamics of complex formation  
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Domańska, U.; Pelczarska, A.; Pobudkowska, A. Effect of 2-Hydroxypropyl-β-cyclodextrin on Solubility of Sparingly Soluble Drug Derivatives of Anthranilic Acid. Int. J. Mol. Sci. 2011, 12, 2383-2394.

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