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Int. J. Mol. Sci. 2011, 12(3), 1991-2006; doi:10.3390/ijms12031991

Effect of Ligusticum wallichii Aqueous Extract on Oxidative Injury and Immunity Activity in Myocardial Ischemic Reperfusion Rats

Department of Cardiology, Fengxian Branch of Shanghai 6th People’s Hospital, Shanghai, 201400 China
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Received: 10 January 2011 / Revised: 22 February 2011 / Accepted: 9 March 2011 / Published: 18 March 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

We investigated the efficacy of Ligusticum wallichi aqueous extract (LWE) for myocardial protection against ischemia-reperfusion injury. Rats were fed for five weeks with either a control diet (sham and ischemia reperfusion (IR) model control groups) or a diet mixed with 0.2%, 0.4% or 0.6% Ligusticum wallichi extract. At the end of the five week period, hearts were excised and subjected to global ischemia for 30 min followed by reperfusion for 2 h. The hearts were compared for indices of oxidative stress and immunity activities. Administration of Ligusticum wallichi extract significantly decreased serum TNF-α, IL-6, IL-8, NO, MIP-1α, CRP and myocardium MDA levels, and serum CK, LDH and AST activities, and increased myocardium Na+-K+-ATPase, Ca2+-Mg2+-ATPase, NOS, SOD, CAT, GSH-Px and TAOC activities. The results indicate that Ligusticum wallichii extract treatment can enhance myocardial antioxidant status and improve the immunity profile in ischemic-reperfusion rats. View Full-Text
Keywords: ischemic reperfusion injury; antioxidant; immunity; Ligusticum wallichii extract ischemic reperfusion injury; antioxidant; immunity; Ligusticum wallichii extract
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zengyong, Q.; Jiangwei, M.; Huajin, L. Effect of Ligusticum wallichii Aqueous Extract on Oxidative Injury and Immunity Activity in Myocardial Ischemic Reperfusion Rats. Int. J. Mol. Sci. 2011, 12, 1991-2006.

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