Int. J. Mol. Sci. 2011, 12(3), 1991-2006; doi:10.3390/ijms12031991
Article

Effect of Ligusticum wallichii Aqueous Extract on Oxidative Injury and Immunity Activity in Myocardial Ischemic Reperfusion Rats

* email, email and email
Received: 10 January 2011; in revised form: 22 February 2011 / Accepted: 9 March 2011 / Published: 18 March 2011
(This article belongs to the Section Bioactives and Nutraceuticals)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: We investigated the efficacy of Ligusticum wallichi aqueous extract (LWE) for myocardial protection against ischemia-reperfusion injury. Rats were fed for five weeks with either a control diet (sham and ischemia reperfusion (IR) model control groups) or a diet mixed with 0.2%, 0.4% or 0.6% Ligusticum wallichi extract. At the end of the five week period, hearts were excised and subjected to global ischemia for 30 min followed by reperfusion for 2 h. The hearts were compared for indices of oxidative stress and immunity activities. Administration of Ligusticum wallichi extract significantly decreased serum TNF-α, IL-6, IL-8, NO, MIP-1α, CRP and myocardium MDA levels, and serum CK, LDH and AST activities, and increased myocardium Na+-K+-ATPase, Ca2+-Mg2+-ATPase, NOS, SOD, CAT, GSH-Px and TAOC activities. The results indicate that Ligusticum wallichii extract treatment can enhance myocardial antioxidant status and improve the immunity profile in ischemic-reperfusion rats.
Keywords: ischemic reperfusion injury; antioxidant; immunity; Ligusticum wallichii extract
PDF Full-text Download PDF Full-Text [179 KB, uploaded 19 June 2014 03:42 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Zengyong, Q.; Jiangwei, M.; Huajin, L. Effect of Ligusticum wallichii Aqueous Extract on Oxidative Injury and Immunity Activity in Myocardial Ischemic Reperfusion Rats. Int. J. Mol. Sci. 2011, 12, 1991-2006.

AMA Style

Zengyong Q, Jiangwei M, Huajin L. Effect of Ligusticum wallichii Aqueous Extract on Oxidative Injury and Immunity Activity in Myocardial Ischemic Reperfusion Rats. International Journal of Molecular Sciences. 2011; 12(3):1991-2006.

Chicago/Turabian Style

Zengyong, Qiao; Jiangwei, Ma; Huajin, Liu. 2011. "Effect of Ligusticum wallichii Aqueous Extract on Oxidative Injury and Immunity Activity in Myocardial Ischemic Reperfusion Rats." Int. J. Mol. Sci. 12, no. 3: 1991-2006.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert