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Int. J. Mol. Sci. 2011, 12(3), 1991-2006; doi:10.3390/ijms12031991
Article

Effect of Ligusticum wallichii Aqueous Extract on Oxidative Injury and Immunity Activity in Myocardial Ischemic Reperfusion Rats

* ,
 and
Department of Cardiology, Fengxian Branch of Shanghai 6th People’s Hospital, Shanghai, 201400 China
* Author to whom correspondence should be addressed.
Received: 10 January 2011 / Revised: 22 February 2011 / Accepted: 9 March 2011 / Published: 18 March 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

We investigated the efficacy of Ligusticum wallichi aqueous extract (LWE) for myocardial protection against ischemia-reperfusion injury. Rats were fed for five weeks with either a control diet (sham and ischemia reperfusion (IR) model control groups) or a diet mixed with 0.2%, 0.4% or 0.6% Ligusticum wallichi extract. At the end of the five week period, hearts were excised and subjected to global ischemia for 30 min followed by reperfusion for 2 h. The hearts were compared for indices of oxidative stress and immunity activities. Administration of Ligusticum wallichi extract significantly decreased serum TNF-α, IL-6, IL-8, NO, MIP-1α, CRP and myocardium MDA levels, and serum CK, LDH and AST activities, and increased myocardium Na+-K+-ATPase, Ca2+-Mg2+-ATPase, NOS, SOD, CAT, GSH-Px and TAOC activities. The results indicate that Ligusticum wallichii extract treatment can enhance myocardial antioxidant status and improve the immunity profile in ischemic-reperfusion rats.
Keywords: ischemic reperfusion injury; antioxidant; immunity; Ligusticum wallichii extract ischemic reperfusion injury; antioxidant; immunity; Ligusticum wallichii extract
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Zengyong, Q.; Jiangwei, M.; Huajin, L. Effect of Ligusticum wallichii Aqueous Extract on Oxidative Injury and Immunity Activity in Myocardial Ischemic Reperfusion Rats. Int. J. Mol. Sci. 2011, 12, 1991-2006.

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