Advances in Carcinogenic Metal Toxicity and Potential Molecular Markers
Abstract
:1. General Features of Carcinogenic Metal Compounds
2. Overall Mechanisms of Metal-Induced Genotoxicity and Carcinogenicity
2.1. Induction of Oxidative Stress, a Causative Source for Metal-Toxicity
2.2. Impairment of DNA Repair Systems and Involvement in Carcinogenesis
2.3. Interruption of Cell Growth Signaling and Its Promotion of Carcinogenesis
3. Revisiting Potential Biomarkers for Metal-Genotoxicity and Carcinogenicity: Interference of Protein-Protein Interactions with Zinc Finger Proteins
3.1. Mammalian DNA Repair Protein XPA
3.2. Poly (ADP-Ribose)Polymerase(PARP)
3.3. Tumor Suppressor Protein p53
4. Enhancement of Antioxidant Defense Systems Responsible for Reducing Metal-Induced Carcinogenicity
4.1. Enzymatic Antioxidants and Their Physiological Response to Metallotoxicity
4.2. Non-Enzymatic Antioxidants and Their Melioration towards Carcinogenesis
5. Conclusion
Acknowledgments
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Koedrith, P.; Seo, Y.R. Advances in Carcinogenic Metal Toxicity and Potential Molecular Markers. Int. J. Mol. Sci. 2011, 12, 9576-9595. https://doi.org/10.3390/ijms12129576
Koedrith P, Seo YR. Advances in Carcinogenic Metal Toxicity and Potential Molecular Markers. International Journal of Molecular Sciences. 2011; 12(12):9576-9595. https://doi.org/10.3390/ijms12129576
Chicago/Turabian StyleKoedrith, Preeyaporn, and Young Rok Seo. 2011. "Advances in Carcinogenic Metal Toxicity and Potential Molecular Markers" International Journal of Molecular Sciences 12, no. 12: 9576-9595. https://doi.org/10.3390/ijms12129576