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Int. J. Mol. Sci. 2011, 12(12), 9596-9604; doi:10.3390/ijms12129596
Article

Synthesis and Insecticidal Activities of New Ester-Derivatives of Celangulin-V

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Received: 17 August 2011; in revised form: 28 October 2011 / Accepted: 15 December 2011 / Published: 20 December 2011
(This article belongs to the Section Green Chemistry)
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Abstract: In order to develop new biorational pesticides, ten new 6-substituted ester derivatives of Celangulin-V were designed and synthesized. The structures of the new derivatives were confirmed by IR, 1H-NMR, 13C-NMR and ESI-MS spectral analysis. Insecticidal activities of these compounds were tested against the third-instar larvae of Mythimna separata. Two derivatives (1.1, 1.2) showed higher insecticidal activities than Celangulin-V, with mortality of 75.0% and 83.3%, respectively. While four compounds (1.3, 1.4, 1.7, 1.8) denoted lower insecticidal activities, the others (1.5, 1.6, 1.9, 1.10) revealed no activities at a concentration of 10 mg.mL−1. The results suggest that C-6 substitutions of Celangulin-V are very important in determining the insecticidal activities of its ester-derivatives. That the acetyl (1.1) and propionyl (1.2) derivatives possessed much higher insecticidal activities than Celangulin-V itself supported the view that Celangulin-V has the potential to be a lead structure of semi-synthetic green insecticides.
Keywords: Celastraceae; dihydroagarofuran; biorational pesticides Celastraceae; dihydroagarofuran; biorational pesticides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhang, J.; Hu, Z.; Li, S.; Wu, W. Synthesis and Insecticidal Activities of New Ester-Derivatives of Celangulin-V. Int. J. Mol. Sci. 2011, 12, 9596-9604.

AMA Style

Zhang J, Hu Z, Li S, Wu W. Synthesis and Insecticidal Activities of New Ester-Derivatives of Celangulin-V. International Journal of Molecular Sciences. 2011; 12(12):9596-9604.

Chicago/Turabian Style

Zhang, Jiwen; Hu, Zhan; Li, Shenkun; Wu, Wenjun. 2011. "Synthesis and Insecticidal Activities of New Ester-Derivatives of Celangulin-V." Int. J. Mol. Sci. 12, no. 12: 9596-9604.



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