Molecular Motor Proteins and Amyotrophic Lateral Sclerosis
Abstract
:1. Introduction
2. Genetics of ALS
3. Possible Pathogenic Mechanisms in ALS
3.1. Protein Misfolding and Aggregation
3.2. Excitotoxicity
3.3. Neuroinflammation
3.4. Mitochondrial Disturbances and Oxidative Stress
3.5. ER Stress
4. Axonal Transport in Neurons
5. Molecular Motor Proteins: Kinesin, Dynein, Myosin
6. Molecular Motors in SOD1-Associated ALS
6.1. Kinesins
6.2. Dyneins
7. Dynein-Mediated ER-Golgi Transport in ALS
7.1. ER-Golgi and Diseases of Motor Neurons
7.2. ER-Golgi Vesicle Trafficking Defects
(a) Vesicle-associated membrane protein-associated protein B (VAPB)
(b) Optineurin
(c) Valosin containing protein (VCP)
8. Do Mutant TDP-43 and Mutant FUS also Induce Molecular Motor Dysfunction?
9. Conclusions
Acknowledgments
References
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Soo, K.Y.; Farg, M.; Atkin, J.D. Molecular Motor Proteins and Amyotrophic Lateral Sclerosis. Int. J. Mol. Sci. 2011, 12, 9057-9082. https://doi.org/10.3390/ijms12129057
Soo KY, Farg M, Atkin JD. Molecular Motor Proteins and Amyotrophic Lateral Sclerosis. International Journal of Molecular Sciences. 2011; 12(12):9057-9082. https://doi.org/10.3390/ijms12129057
Chicago/Turabian StyleSoo, Kai Y, Manal Farg, and Julie D. Atkin. 2011. "Molecular Motor Proteins and Amyotrophic Lateral Sclerosis" International Journal of Molecular Sciences 12, no. 12: 9057-9082. https://doi.org/10.3390/ijms12129057