Abstract: The present study was aimed at evaluating the antinociceptive and anti-inflammatory effects of the ethanol extract from Vernonia condensata leaves in animal models, in order to afford a better understanding of these properties. The extract reduced the number of abdominal contortions at doses of 100 (51.00 ± 3.00), 200 (42.00 ± 2.98) and 400 mg/kg (39.00 ± 4.00). In formalin tests, a significant reduction in the licking time (p < 0.01) was observed in the first phase by 25.14 (200 mg/kg = 51.50 ± 4.44) and 31.15% (400 mg/kg = 48.00 ± 4.37). The doses of 100 (43.37 ± 5.15), 200 (34.62 ± 4.16) and 400 mg/kg (28.37 ± 3.98) inhibited (p < 0.001) the second phase. After 60 and 90 min of treatment, a dose of 400 mg/kg (10.13 ± 0.39 and 11.14 ± 1.33, respectively) increased the latency time. Doses of 200 and 400 mg/kg potentiated the sleeping time induced by diazepam, pentobarbital and meprobamate. The extracts (100, 200 and 400 mg/kg) showed anti-inflammatory effects by a decrease in paw edema. The extracts also reduced the exudate volume at the doses of 200 and 400 mg/kg. The leukocyte migration had significant effect (p < 0.001) at doses of 100, 200 and 400 mg/kg. The completion of additional experiments in the investigation of the antinociceptive and anti-inflammatory activities of V. condensata allowed a better understanding of the central and peripheral mechanisms involved.
Keywords: Vernonia condensata; antinociceptive activity; sedative effect; anti-inflammatory activity
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da Silva, J.B.; Temponi, V.S.; Fernandes, F.V.; Alves, G.A.D.; Matos, D.M.; Gasparetto, C.M.; Ribeiro, A.; de Pinho, J.J.R.G.; Alves, M.S.; de Sousa, O.V. New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves. Int. J. Mol. Sci. 2011, 12, 8993-9008.
da Silva JB, Temponi VS, Fernandes FV, Alves GAD, Matos DM, Gasparetto CM, Ribeiro A, de Pinho JJRG, Alves MS, de Sousa OV. New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves. International Journal of Molecular Sciences. 2011; 12(12):8993-9008.
da Silva, Jucélia Barbosa; Temponi, Vanessa dos Santos; Fernandes, Felipe Valente; Alves, Geórgia de Assis Dias; Matos, Dalyara Mendonça de; Gasparetto, Carolina Miranda; Ribeiro, Antônia; de Pinho, José de Jesus R. G.; Alves, Maria Silvana; de Sousa, Orlando Vieira. 2011. "New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves." Int. J. Mol. Sci. 12, no. 12: 8993-9008.