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Int. J. Mol. Sci. 2011, 12(12), 8993-9008; doi:10.3390/ijms12128993
Article

New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves

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Received: 14 October 2011; in revised form: 8 November 2011 / Accepted: 23 November 2011 / Published: 7 December 2011
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: The present study was aimed at evaluating the antinociceptive and anti-inflammatory effects of the ethanol extract from Vernonia condensata leaves in animal models, in order to afford a better understanding of these properties. The extract reduced the number of abdominal contortions at doses of 100 (51.00 ± 3.00), 200 (42.00 ± 2.98) and 400 mg/kg (39.00 ± 4.00). In formalin tests, a significant reduction in the licking time (p < 0.01) was observed in the first phase by 25.14 (200 mg/kg = 51.50 ± 4.44) and 31.15% (400 mg/kg = 48.00 ± 4.37). The doses of 100 (43.37 ± 5.15), 200 (34.62 ± 4.16) and 400 mg/kg (28.37 ± 3.98) inhibited (p < 0.001) the second phase. After 60 and 90 min of treatment, a dose of 400 mg/kg (10.13 ± 0.39 and 11.14 ± 1.33, respectively) increased the latency time. Doses of 200 and 400 mg/kg potentiated the sleeping time induced by diazepam, pentobarbital and meprobamate. The extracts (100, 200 and 400 mg/kg) showed anti-inflammatory effects by a decrease in paw edema. The extracts also reduced the exudate volume at the doses of 200 and 400 mg/kg. The leukocyte migration had significant effect (p < 0.001) at doses of 100, 200 and 400 mg/kg. The completion of additional experiments in the investigation of the antinociceptive and anti-inflammatory activities of V. condensata allowed a better understanding of the central and peripheral mechanisms involved.
Keywords: Vernonia condensata; antinociceptive activity; sedative effect; anti-inflammatory activity Vernonia condensata; antinociceptive activity; sedative effect; anti-inflammatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

da Silva, J.B.; Temponi, V.S.; Fernandes, F.V.; Alves, G.A.D.; Matos, D.M.; Gasparetto, C.M.; Ribeiro, A.; de Pinho, J.J.R.G.; Alves, M.S.; de Sousa, O.V. New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves. Int. J. Mol. Sci. 2011, 12, 8993-9008.

AMA Style

da Silva JB, Temponi VS, Fernandes FV, Alves GAD, Matos DM, Gasparetto CM, Ribeiro A, de Pinho JJRG, Alves MS, de Sousa OV. New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves. International Journal of Molecular Sciences. 2011; 12(12):8993-9008.

Chicago/Turabian Style

da Silva, Jucélia Barbosa; Temponi, Vanessa dos Santos; Fernandes, Felipe Valente; Alves, Geórgia de Assis Dias; Matos, Dalyara Mendonça de; Gasparetto, Carolina Miranda; Ribeiro, Antônia; de Pinho, José de Jesus R. G.; Alves, Maria Silvana; de Sousa, Orlando Vieira. 2011. "New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves." Int. J. Mol. Sci. 12, no. 12: 8993-9008.


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