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Int. J. Mol. Sci. 2011, 12(12), 8836-8845; doi:10.3390/ijms12128836

The Effect of Raw Soybean on Oxidative Status of Digestive Organs in Mice

1
Institute of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China
2
Institute of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin 130118, China
*
Author to whom correspondence should be addressed.
Received: 23 October 2011 / Revised: 10 November 2011 / Accepted: 21 November 2011 / Published: 2 December 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The present study was undertaken to specify the effect of raw soybean on oxidative status of digestive organs in mice. For this purpose, thirty male (C57BL/6J) mice were randomly divided into three groups and fed on different diets as follows: Group 1 was fed on control diet, Group 2 was fed on raw soybean diet and Group 3 was fed on raw soybean diet supplemented with 30 mg/kg cysteamine. After two weeks of feeding, duodenum, liver and pancreas samples were collected to measure oxidative and antioxidative parameters. The results show that ingestion of raw soybean markedly increased contents of superoxide anion and malondialdehyde (MDA) and activity of inducible nitric oxide synthase (iNOS), decreased activity of superoxide dismutase (SOD), T-AOC and content of reduced glutathione (GSH) in digestive organs of mice (P < 0.05). In the group fed with raw soybean diet supplemented with cysteamine, oxidative stress was mitigated. However, oxidative parameter levels were still higher than those of control diet-fed group. The present study indicates that ingestion of raw soybean could result in an imbalance between oxidant and antioxidant, and thus induce oxidative stress in digestive organs of mice. View Full-Text
Keywords: anti-nutritional factors; digestive organs; free radical; mice; raw soybean anti-nutritional factors; digestive organs; free radical; mice; raw soybean
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Gu, C.; Qu, H.; Han, L.; Song, X.; Zhao, L.; Lu, W. The Effect of Raw Soybean on Oxidative Status of Digestive Organs in Mice. Int. J. Mol. Sci. 2011, 12, 8836-8845.

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