Int. J. Mol. Sci. 2011, 12(12), 8836-8845; doi:10.3390/ijms12128836
Article

The Effect of Raw Soybean on Oxidative Status of Digestive Organs in Mice

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Received: 23 October 2011; in revised form: 10 November 2011 / Accepted: 21 November 2011 / Published: 2 December 2011
(This article belongs to the Section Bioactives and Nutraceuticals)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The present study was undertaken to specify the effect of raw soybean on oxidative status of digestive organs in mice. For this purpose, thirty male (C57BL/6J) mice were randomly divided into three groups and fed on different diets as follows: Group 1 was fed on control diet, Group 2 was fed on raw soybean diet and Group 3 was fed on raw soybean diet supplemented with 30 mg/kg cysteamine. After two weeks of feeding, duodenum, liver and pancreas samples were collected to measure oxidative and antioxidative parameters. The results show that ingestion of raw soybean markedly increased contents of superoxide anion and malondialdehyde (MDA) and activity of inducible nitric oxide synthase (iNOS), decreased activity of superoxide dismutase (SOD), T-AOC and content of reduced glutathione (GSH) in digestive organs of mice (P < 0.05). In the group fed with raw soybean diet supplemented with cysteamine, oxidative stress was mitigated. However, oxidative parameter levels were still higher than those of control diet-fed group. The present study indicates that ingestion of raw soybean could result in an imbalance between oxidant and antioxidant, and thus induce oxidative stress in digestive organs of mice.
Keywords: anti-nutritional factors; digestive organs; free radical; mice; raw soybean
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MDPI and ACS Style

Gu, C.; Qu, H.; Han, L.; Song, X.; Zhao, L.; Lu, W. The Effect of Raw Soybean on Oxidative Status of Digestive Organs in Mice. Int. J. Mol. Sci. 2011, 12, 8836-8845.

AMA Style

Gu C, Qu H, Han L, Song X, Zhao L, Lu W. The Effect of Raw Soybean on Oxidative Status of Digestive Organs in Mice. International Journal of Molecular Sciences. 2011; 12(12):8836-8845.

Chicago/Turabian Style

Gu, Chunmei; Qu, Hongsheng; Han, Lingling; Song, Xinxiu; Zhao, Linlin; Lu, Wenfa. 2011. "The Effect of Raw Soybean on Oxidative Status of Digestive Organs in Mice." Int. J. Mol. Sci. 12, no. 12: 8836-8845.

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