Next Article in Journal
Biomarkers in Tumor Angiogenesis and Anti-Angiogenic Therapy
Next Article in Special Issue
Effect of Byrsonima crassa and Phenolic Constituents on Helicobacter pylori-Induced Neutrophils Oxidative Burst
Previous Article in Journal
Biological Potential of Sixteen Legumes in China
Previous Article in Special Issue
N-Acetylcysteine Reduces Markers of Differentiation in 3T3-L1 Adipocytes
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2011, 12(10), 7059-7076; doi:10.3390/ijms12107059

Anti-UVC Irradiation and Metal Chelation Properties of 6-Benzoyl-5,7-dihydroxy-4-phenyl-chromen-2-one: An Implications for Anti-Cataract Agent

Institute of Biological Chemistry, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan
School of Pharmacy, College of Pharmacy, Taipei Medical University, 250 Wuxing Street, Taipei 11031, Taiwan
Institute of Biochemical Sciences, National Taiwan University, No. 1, Section 4, Roosevelt Road, Taipei 10617, Taiwan
Authors to whom correspondence should be addressed.
Received: 29 July 2011 / Revised: 23 September 2011 / Accepted: 11 October 2011 / Published: 21 October 2011
(This article belongs to the Special Issue Antioxidants)
View Full-Text   |   Download PDF [719 KB, uploaded 19 June 2014]   |  


Coumarin derivative 1, 5,7-dihydroxy-6-(3-methyl-1-butyryl)-4-phenyl-chromen-2-one, has been reported to possess radical scavenging activity and DNA protection. We have synthesized a series of coumarins with structural modifications at positions C4, C5, C6 and C7 and evaluated them for their anti-UVC properties. Coumarin 7, 6-benzoyl-5,6-dihydroxy-4-phenyl-chromen-2-one, was found to have the most potent activity in protecting porcine γ-crystallin against UVC insults. Results of fluorescence assays indicated that compound 7 was capable of decreasing the loss of intensity while lens crystallins and DNA PUC19 were irradiated with UVC. Presence of compound 7 decreased hydroxyl radical levels determined by probe 1b and the free iron concentrations determined by Ferrozine reagent. The chelation assay showed that compound 7 was chelated to metal via 6-CO and 5-OH on the benzopyrone ring. The observed protective effects of compound 7 towards crystallins from insults of UVC and free radicals may be due to its iron-chelating activity and its peak absorption at 254 nm.
Keywords: irradiation; anti-cataract; coumarin; γ-crystallin; iron-chelation irradiation; anti-cataract; coumarin; γ-crystallin; iron-chelation

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Liao, J.-H.; Wu, T.-H.; Hsu, F.-L.; Huang, Y.-S.; Chiang, P.-H.; Huang, Z.-Y.; Huang, C.-H.; Wu, S.-H.; Lin, M.-H. Anti-UVC Irradiation and Metal Chelation Properties of 6-Benzoyl-5,7-dihydroxy-4-phenyl-chromen-2-one: An Implications for Anti-Cataract Agent. Int. J. Mol. Sci. 2011, 12, 7059-7076.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top