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Biomarkers in Tumor Angiogenesis and Anti-Angiogenic Therapy
Hematology and Oncology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
Department of Urology and Division of Experimental Urology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
Tumor Center Unisantus, Custodisstrasse 3-17, 50679 Köln, Germany
Hematology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
* Author to whom correspondence should be addressed.
Received: 15 August 2011; Accepted: 9 October 2011 / Published: 21 October 2011
Abstract: Tumor angiogenesis has been identified to play a critical role in tumor growth and tumor progression, and is regulated by a balance of angiogenic and anti-angiogenic cytokines. Among them VEGF (vascular endothelial growth factor) and its signaling through its receptors are of crucial relevance. Inhibition of VEGF signaling by monoclonal antibodies or small molecules (kinase inhibitors) has already been successfully established for the treatment of different cancer entities and multiple new drugs are being tested in clinical trials. However not all patients are likely to respond to these therapies, but to date there are no reliable biomarkers available to predict therapy response. Many studies integrated biomarker programs in their study protocols, thus several potential biomarkers have been identified which are currently under clinical investigation in prospective randomized studies. This review intends to give an overview of the described potential biomarkers as well as different imaging techniques such as ultrasound and magnetic resonance imaging that can indicate benefit, resistance and toxicity to anti-angiogenic therapies.
Keywords: angiogenesis; biomarkers; imaging techniques; vascular endothelial growth factor
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Pircher, A.; Hilbe, W.; Heidegger, I.; Drevs, J.; Tichelli, A.; Medinger, M. Biomarkers in Tumor Angiogenesis and Anti-Angiogenic Therapy. Int. J. Mol. Sci. 2011, 12, 7077-7099.
Pircher A, Hilbe W, Heidegger I, Drevs J, Tichelli A, Medinger M. Biomarkers in Tumor Angiogenesis and Anti-Angiogenic Therapy. International Journal of Molecular Sciences. 2011; 12(10):7077-7099.
Pircher, Andreas; Hilbe, Wolfgang; Heidegger, Isabel; Drevs, Joachim; Tichelli, André; Medinger, Michael. 2011. "Biomarkers in Tumor Angiogenesis and Anti-Angiogenic Therapy." Int. J. Mol. Sci. 12, no. 10: 7077-7099.