Expression of Elongation Factor (EF)-Tu Is Correlated with Prognosis of Gastric Adenocarcinomas
Abstract
:1. Introduction
2. Materials and Methods
2.1. Case Selection
2.2. Immunohistochemistry
2.3. Follow Up
2.4. Statistical Analysis
3. Results
3.1. EF-Tu Expression Correlates with Clinicopathologic Parameters
3.2. Univariate Analysis
3.3. Multivariate Analysis
4. Discussion
Acknowledgement
References
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Negative/low (n = 55) | High (n = 49) | P value | |
---|---|---|---|
Age | 54.9 ± 11.3 | 57.2 ± 12.5 | 0.329 |
Gender | 0.104 | ||
Male | 40 (61.5%) | 28 (51.7) | |
Female | 15 (38.5%) | 21 (48.3) | |
ECOG | 0.544 | ||
0 | 18 (32.7) | 17 (35.4) | |
1 | 37 (67.3) | 31 (62.5) | |
2 | 0 | 1 (2.1) | |
Type of operation | 1.000 | ||
Total gastrectomy | 6 (10.9) | 5 (10.2) | |
Subtotal gastrectomy | 49 (89.1) | 44 (89.8) |
Negative/low (n = 55) | High (n = 49) | P value | |
---|---|---|---|
Location | 0.753 | ||
Upper body or whole | 13 (23.6) | 9 (18.5) | |
Lower or middle body | 42 (76.4) | 40 (81.5) | |
Tumor differentiated | 0.061 | ||
Well | 7 (12.7) | 2 (4.1) | |
Moderate | 14 (25.5) | 22 (40.0) | |
Poor | 34 (61.8) | 25 (55.9) | |
Tumor size | 5.3 ± 2.3 | 4.3 ± 2.0 | 0.021 |
Serosal invasion | 0.042 | ||
No | 14 (25.5) | 22 (44.9) | |
Yes | 41 (74.5) | 27 (55.1) | |
Node involveme | 0.005 | ||
No | 13 (23.6) | 25 (51.0) | |
Yes | 42 (76.4) | 24 (49.0) | |
Mean no. of tLNs | 21 | 19 | 0.489 |
Distant metastasis | 1.000 | ||
No | 48 (87.3) | 43 (23.6) | |
Yes | 7 (12.7) | 6 (23.6) | |
Normal specimens EF-Tu expression | 0.015 | ||
Negative/low | 27 (49.1) | 12 (24.5) | |
High | 28 (50.9) | 37 (75.5) |
Variable | HR | 95% CI | P * value |
---|---|---|---|
EF-Tu | 0.460 | 0.220–0.960 | 0.038 |
Distant metastasis | 4.323 | 1.442–12.963 | 0.009 |
Serosal invasion (yes vs. no) | 6.242 | 1.808–21.548 | 0.004 |
mLNs | 1.082 | 1.001–1.169 | 0.047 |
tLNs | 0.053 | ||
Type of operation | 0.096 | ||
Age (years) (>55 vs ≤55) | 0.187 | ||
Tumor size (≦4 cm vs >4 cm) | 0.547 | ||
Histological type (undifferentiated vs differentiated) | 0.812 | ||
Gender | 0.810 | ||
Tumor location | 0.856 |
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Xu, C.; Wang, J.; Li, J.; Fang, R. Expression of Elongation Factor (EF)-Tu Is Correlated with Prognosis of Gastric Adenocarcinomas. Int. J. Mol. Sci. 2011, 12, 6645-6655. https://doi.org/10.3390/ijms12106645
Xu C, Wang J, Li J, Fang R. Expression of Elongation Factor (EF)-Tu Is Correlated with Prognosis of Gastric Adenocarcinomas. International Journal of Molecular Sciences. 2011; 12(10):6645-6655. https://doi.org/10.3390/ijms12106645
Chicago/Turabian StyleXu, Chaoyang, Jianjun Wang, Jiajia Li, and Rengui Fang. 2011. "Expression of Elongation Factor (EF)-Tu Is Correlated with Prognosis of Gastric Adenocarcinomas" International Journal of Molecular Sciences 12, no. 10: 6645-6655. https://doi.org/10.3390/ijms12106645