Int. J. Mol. Sci. 2011, 12(10), 6635-6644; doi:10.3390/ijms12106635
Article

Quantitative Comparative Analysis of the Bio-Active and Toxic Constituents of Leaves and Spikes of Schizonepeta tenuifolia at Different Harvesting Times

Sheng Yuemail, Yiwen Chenemail, Li Zhang* email, Mingqiu Shanemail, Yuping Tangemail and Anwei Ding* email
Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210046, China
* Authors to whom correspondence should be addressed.
Received: 26 July 2011; in revised form: 26 September 2011 / Accepted: 28 September 2011 / Published: 10 October 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: A GC-MS-Selected Ion Monitoring (SIM) detection method was developed for simultaneous determination of four monoterpenes: (-)-menthone, (+)-pulegone, (-)-limonene and (+)-menthofuran as the main bio-active and toxic constituents, and four other main compounds in the volatile oils of Schizonepeta tenuifolia (ST) leaves and spikes at different harvesting times. The results showed that the method was simple, sensitive and reproducible, and that harvesting time was a possible key factor in influencing the quality of ST leaves, but not its spikes. The research might be helpful for determining the harvesting time of ST samples and establishing a validated method for the quality control of ST volatile oil and other relative products.
Keywords: Schizonepeta tenuifolia; menthone; pulegone; limonene; menthofuran; harvesting time

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MDPI and ACS Style

Yu, S.; Chen, Y.; Zhang, L.; Shan, M.; Tang, Y.; Ding, A. Quantitative Comparative Analysis of the Bio-Active and Toxic Constituents of Leaves and Spikes of Schizonepeta tenuifolia at Different Harvesting Times. Int. J. Mol. Sci. 2011, 12, 6635-6644.

AMA Style

Yu S, Chen Y, Zhang L, Shan M, Tang Y, Ding A. Quantitative Comparative Analysis of the Bio-Active and Toxic Constituents of Leaves and Spikes of Schizonepeta tenuifolia at Different Harvesting Times. International Journal of Molecular Sciences. 2011; 12(10):6635-6644.

Chicago/Turabian Style

Yu, Sheng; Chen, Yiwen; Zhang, Li; Shan, Mingqiu; Tang, Yuping; Ding, Anwei. 2011. "Quantitative Comparative Analysis of the Bio-Active and Toxic Constituents of Leaves and Spikes of Schizonepeta tenuifolia at Different Harvesting Times." Int. J. Mol. Sci. 12, no. 10: 6635-6644.

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