Next Article in Journal
A Determination of Potential α-Glucosidase Inhibitors from Azuki Beans (Vigna angularis)
Previous Article in Journal
Genetic Variation of the Nile Soft-Shelled Turtle (Trionyx triunguis)
Int. J. Mol. Sci. 2011, 12(10), 6432-6444; doi:10.3390/ijms12106432
Article

Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents

1
 and 2,3,*
1 Pharmaceutical Chemistry Department, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia, Bucharest 020956, Romania 2 Microbiology Immunology Department, Faculty of Biology, University of Bucharest, Ale. Portocalelor 1-3, Buhcarest 60101, Romania 3 National Institute of Research and Development for Microbiology and Immunology Cantacuzino, 103 Spl. Independentei, Bucharest 060631, Romania
* Author to whom correspondence should be addressed.
Received: 21 July 2011 / Revised: 29 August 2011 / Accepted: 14 September 2011 / Published: 28 September 2011
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
View Full-Text   |   Download PDF [296 KB, 19 June 2014; original version 19 June 2014]   |   Browse Figures

Abstract

In this paper we present the antimicrobial activity of some newly synthesized dibenz[b,e]oxepin derivatives bearing the oximino moiety, and fluorine (F) and trifluoromethyl (CF3) group substituents. The chemical structure and purity of the new compounds were assessed by using elemental analysis, NMR and FTIR spectroscopy. The new compounds were screened for their antibacterial activity towards Gram-positive and Gram-negative strains, by qualitative and quantitative assays. Our results demonstrated that the CF3 and F disubstituted compounds could be considered for the further development of novel antimicrobial drugs.
Keywords: dibenz[b,e]oxepin; methanone derivatives; antibacterial activity; gram-positive; gram-negative dibenz[b,e]oxepin; methanone derivatives; antibacterial activity; gram-positive; gram-negative
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Limban, C.; Chifiriuc, M.C. Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents. Int. J. Mol. Sci. 2011, 12, 6432-6444.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert