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Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents
Pharmaceutical Chemistry Department, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia, Bucharest 020956, Romania
Microbiology Immunology Department, Faculty of Biology, University of Bucharest, Ale. Portocalelor 1-3, Buhcarest 60101, Romania
National Institute of Research and Development for Microbiology and Immunology Cantacuzino, 103 Spl. Independentei, Bucharest 060631, Romania
* Author to whom correspondence should be addressed.
Received: 21 July 2011; in revised form: 29 August 2011 / Accepted: 14 September 2011 / Published: 28 September 2011
Abstract: In this paper we present the antimicrobial activity of some newly synthesized dibenz[b,e]oxepin derivatives bearing the oximino moiety, and fluorine (F) and trifluoromethyl (CF3) group substituents. The chemical structure and purity of the new compounds were assessed by using elemental analysis, NMR and FTIR spectroscopy. The new compounds were screened for their antibacterial activity towards Gram-positive and Gram-negative strains, by qualitative and quantitative assays. Our results demonstrated that the CF3 and F disubstituted compounds could be considered for the further development of novel antimicrobial drugs.
Keywords: dibenz[b,e]oxepin; methanone derivatives; antibacterial activity; gram-positive; gram-negative
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Limban, C.; Chifiriuc, M.C. Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents. Int. J. Mol. Sci. 2011, 12, 6432-6444.
Limban C, Chifiriuc MC. Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents. International Journal of Molecular Sciences. 2011; 12(10):6432-6444.
Limban, Carmen; Chifiriuc, Mariana Carmen. 2011. "Antibacterial Activity of New Dibenzoxepinone Oximes with Fluorine and Trifluoromethyl Group Substituents." Int. J. Mol. Sci. 12, no. 10: 6432-6444.