Human Umbilical Cord Blood Stem Cells: Rational for Use as a Neuroprotectant in Ischemic Brain Disease
Abstract
:1. Introduction
2. CB—An Attractive Potential Source for Brain Regeneration
3. Neural Stem Cells from CB—An Unclear Origin
4. Therapeutic Effect by CB-Derived Cells on Ischemic Brain Injury
5. CB-Induced Therapeutic Effect on Ischemic Brain Injury—Routes for Mediating Mechanisms
6. Therapeutic Effect of CB-Derived Cells on Ischemic Brain Injury—A Glance to the Future
7. Conclusions
Acknowledgments
References
- Raedt, R; Boon, P. Cell therapy for neurological disorders: A comprehensive review. Acta Neurol. Belg 2005, S105, 158–170. [Google Scholar]
- Unsicker, K. The trophic cocktail made by adrenal chromaffin cells. Exp. Neurol 1993, 123, 167–173. [Google Scholar]
- Lazic, SE; Barker, RA. The future of cell-based transplantation therapies for neurodegenerative disorders. J. Hematother. Stem Cell Res 2003, 12, 635–642. [Google Scholar]
- Kennea, NL; Mehmet, H. Neural stem cells. J. Pathol 2002, 197, 536–550. [Google Scholar]
- Suter, DM; Krause, KH. Neural commitment of embryonic stem cells: Molecules, pathways and potential for cell therapy. J. Pathol 2008, 215, 355–368. [Google Scholar]
- Duan, X; Kang, E; Liu, CY; Ming, GL; Song, H. Development of neural stem cell in the adult brain. Curr. Opin. Neurobiol 2008, 18, 108–115. [Google Scholar]
- Nunes, MC; Roy, NS; Keyoung, HM; Goodman, RR; McKhann, G, II; Jiang, L; Kang, J; Nedergaard, M; Goldman, SA. Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nat. Med 2003, 9, 439–447. [Google Scholar]
- Harris, DT. Cord blood stem cells: A review of potential neurological applications. Stem Cell Rev 2008, 4, 269–274. [Google Scholar]
- Arien-Zakay, H; Lazarovici, P; Nagler, A. Tissue regeneration potential in human umbilical cord blood. Best Pract. Res. Clin. Haematol 2010. [Google Scholar] [CrossRef]
- Daley, GQ; Goodell, MA; Snyder, EY. Realistic prospects for stem cell therapeutics. Hematol. Am. Soc. Hematol. Ed. Prog 2003, 398–418. [Google Scholar]
- Gardner, RL. Stem cells and regenerative medicine: Principles, prospects and problems. C. R. Biol 2007, 330, 465–473. [Google Scholar]
- Stanevsky, A; Goldstein, G; Nagler, A. Umbilical cord blood transplantation: Pros, cons and beyond. Blood Rev 2009, 23, 199–204. [Google Scholar]
- van de Ven, C; Collins, D; Bradley, MB; Morris, E; Cairo, MS. The potential of umbilical cord blood multipotent stem cells for nonhematopoietic tissue and cell regeneration. Exp. Hematol 2007, 35, 1753–1765. [Google Scholar]
- Rocha, V; Wagner, JE, Jr; Sobocinski, KA; Klein, JP; Zhang, MJ; Horowitz, MM; Gluckman, E. Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-identical sibling. Eurocord and international bone marrow transplant registry working committee on alternative donor and stem cell sources. N. Engl. J. Med 2000, 342, 1846–1854. [Google Scholar]
- Bone Marrow Donors Worldwide, Annual report, 2009. Available online: http://www.bmdw.org/uploads/media/BMDW2009.pdf (accessed on 15 September 2010).
- Stanevsky, A; Shimoni, A; Yerushalmi, R; Nagler, A. Double umbilical cord blood transplant: More than a cell dose? Leuk Lymphoma 2010, 51, 975–982. [Google Scholar]
- Arien-Zakay, H; Nagler, A; Galski, H; Lazarovici, P. Neuronal conditioning medium and nerve growth factor induce neuronal differentiation of collagen-adherent progenitors derived from human umbilical cord blood. J. Mol. Neurosci 2007, 32, 179–191. [Google Scholar]
- Arien-Zakay, H; Lecht, S; Bercu, MM; Amariglio, N; Rechavi, G; Galski, H; Lazarovici, P; Nagler, A. Interferon-gamma-induced neuronal differentiation of human umbilical cord blood-derived progenitors. Leukemia 2009, 23, 1790–1800. [Google Scholar]
- Sanchez-Ramos, JR; Song, S; Kamath, SG; Zigova, T; Willing, A; Cardozo-Pelaez, F; Stedeford, T; Chopp, M; Sanberg, PR. Expression of neural markers in human umbilical cord blood. Exp. Neurol 2001, 171, 109–115. [Google Scholar]
- Buzanska, L; Machaj, EK; Zablocka, B; Pojda, Z; Domanska-Janik, K. Human cord blood-derived cells attain neuronal and glial features in vitro. J. Cell Sci 2002, 115, 2131–2138. [Google Scholar]
- Jang, YK; Park, JJ; Lee, MC; Yoon, BH; Yang, YS; Yang, SE; Kim, SU. Retinoic acidmediated induction of neurons and glial cells from human umbilical cord-derived hematopoietic stem cells. J. Neurosci. Res 2004, 75, 573–584. [Google Scholar]
- Habich, A; Jurga, M; Markiewicz, I; Lukomska, B; Bany-Laszewicz, U; Domanska-Janik, K. Early appearance of stem/progenitor cells with neural-like characteristics in human cord blood mononuclear fraction cultured in vitro. Exp. Hematol 2006, 34, 914–925. [Google Scholar]
- Jeong, JA; Gang, EJ; Hong, SH; Hwang, SH; Kim, SW; Yang, IH; Ahn, C; Han, H; Kim, H. Rapid neural differentiation of human cord blood-derived mesenchymal stem cells. Neuroreport 2004, 15, 1731–1734. [Google Scholar]
- Ha, Y; Choi, JU; Yoon, DH; Yeon, DS; Lee, JJ; Kim, HO; Cho, YE. Neural phenotype expression of cultured human cord blood cells in vitro. Neuroreport 2001, 12, 3523–3527. [Google Scholar]
- Sun, W; Buzanska, L; Domanska-Janik, K; Salvi, RJ; Stachowiak, MK. Voltage-sensitive and ligand-gated channels in differentiating neural stem-like cells derived from the nonhematopoietic fraction of human umbilical cord blood. Stem Cells 2005, 23, 931–945. [Google Scholar]
- Mcguckin, CP; Forraz, N; Allouard, Q; Pettengell, R. Umbilical cord blood stem cells can expand hematopoietic and neuroglial progenitors in vitro. Exp. Cell Res 2004, 295, 350–359. [Google Scholar]
- Chen, N; Hudson, JE; Walczak, P; Misiuta, I; Garbuzova-Davis, S; Jiang, L; Sanchez-Ramos, J; Sanberg, PR; Zigova, T; Willing, AE. Human umbilical cord blood progenitors: The potential of these hematopoietic cells to become neural. Stem Cells 2005, 23, 1560–1570. [Google Scholar]
- Buzanska, L; Jurga, M; Stachowiak, EK; Stachowiak, MK; Domańska-Janik, K. Neural stem-like cell line derived from a nonhematopoietic population of human umbilical cord blood. Stem Cells Dev 2006, 15, 391–406. [Google Scholar]
- Rogers, I; Yamanaka, N; Bielecki, R; Wong, CJ; Chua, S; Yuen, S; Casper, RF. Identification and analysis of in vitro cultured CD45-positive cells capable of multi-lineage differentiation. Exp. Cell Res 2007, 313, 1839–1852. [Google Scholar]
- Bracci-Laudiero, L; Celestino, D; Starace, G; Antonelli, A; Lambiase, A; Procoli, A; Rumi, C; Lai, M; Picardi, A; Ballatore, G; et al. CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA. J. Neuroimmunol 2003, 136, 130–139. [Google Scholar]
- Zangiacomi, V; Balon, N; Maddens, S; Lapierre, V; Tiberghien, P; Schlichter, R; Versaux-Botteri, C; Deschaseaux, F. Cord blood-derived neurons are originated from CD133+/CD34 stem/progenitor cells in a cell-to-cell contact dependent manner. Stem Cells Dev 2008, 17, 1005–1016. [Google Scholar]
- Lee, OK; Kuo, TK; Chen, WM; Lee, KD; Hsieh, SL; Chen, TH. Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood 2004, 103, 1669–1675. [Google Scholar]
- Kogler, G; Sensken, S; Airey, JA; Trapp, T; Müschen, M; Feldhahn, N; Liedtke, S; Sorg, RV; Fischer, J; Rosenbaum, C; et al. A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J. Exp. Med 2004, 200, 123–135. [Google Scholar]
- Kogler, G; Sensken, S; Wernet, P. Comparative generation and characterization of pluripotent unrestricted somatic stem cells with mesenchymal stem cells from human cord blood. Exp. Hematol 2006, 34, 1589–1595. [Google Scholar]
- Oh, W; Kim, DS; Yang, YS; Lee, JK. Immunological properties of umbilical cord blood-derived mesenchymal stromal cells. Cell Immunol 2008, 251, 116–123. [Google Scholar]
- Bobis, S; Jarocha, D; Majka, M. Mesenchymal stem cells: Characteristics and clinical applications. Folia Histochem. Cytobiol 2006, 44, 215–230. [Google Scholar]
- Goodwin, HS; Bicknese, AR; Chien, SN; Bogucki, BD; Quinn, CO; Wall, DA. Multilineage differentiation activity by cells isolated from umbilical cord blood: Expression of bone, fat, and neural markers. Biol. Blood Marrow. Transplant 2001, 7, 581–588. [Google Scholar]
- Lim, JY; Park, SI; Oh, JH; Kim, SM; Jeong, CH; Jun, JA; Lee, KS; Oh, W; Lee, JK; Jeun, SS. Brain-derived neurotrophic factor stimulates the neural differentiation of human umbilical cord blood-derived mesenchymal stem cells and survival of differentiated cells through MAPK/ERK and PI3K/Akt-dependent signaling pathways. J. Neurosci. Res 2008, 86, 2168–2178. [Google Scholar]
- Kohyama, J; Abe, H; Shimazaki, T; Koizumi, A; Nakashima, K; Gojo, S; Taga, T; Okano, H; Hata, J; Umezawa, A. Brain from bone: Efficient “meta-differentiation” of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agent. Differentiation 2001, 68, 235–244. [Google Scholar]
- Vajda, FJ. Neuroprotection and neurodegenerative disease. J. Clin. Neurosci 2002, 9, 4–8. [Google Scholar]
- Wahlgren, NG; Ahmed, N. Neuroprotection in cerebral ischaemia: Facts and fancies-the need for new approaches. Cerebrovasc. Dis 2004, 1, 153–166. [Google Scholar]
- Zhang, RL; Zhang, ZG; Chopp, M. Neurogenesis in the adult ischemic brain: Generation, migration, survival, and restorative therapy. Neuroscientist 2005, 11, 408–416. [Google Scholar]
- Weinberger, JM. Evolving therapeutic approaches to treating acute ischemic stroke. J. Neurol. Sci 2006, 249, 101–109. [Google Scholar]
- Chang, YC; Shyu, WC; Lin, SZ; Li, H. Regenerative therapy for stroke. Cell Transplant 2007, 16, 171–181. [Google Scholar]
- Chen, J; Sanberg, PR; Li, Y; Wang, L; Lu, M; Willing, AE; Sanchez-Ramos, J; Chopp, M. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke 2001, 32, 2682–2688. [Google Scholar]
- Newman, MB; Willing, AE; Manresa, JJ; Davis-Sanberg, C; Sanberg, PR. Stroke-induced migration of human umbilical cord blood cells: Time course and cytokines. Stem Cells Dev 2005, 14, 576–586. [Google Scholar]
- Vendrame, M; Cassady, J; Newcomb, J; Butler, T; Pennypacker, KR; Zigova, T; Sanberg, CD; Sanberg, PR; Willing, AE. Infusion of human umbilical cord blood cells in a rat model of stroke dosedependently rescues behavioral deficits and reduces infarct volume. Stroke 2004, 35, 2390–2395. [Google Scholar]
- Willing, AE; Lixian, J; Milliken, M; Poulos, S; Zigova, T; Song, S; Hart, C; Sanchez- Ramos, J; Sanberg, PR. Intravenous versus intrastriatal cord blood administration in a rodent model of stroke. J. Neurosci. Res 2003, 73, 296–307. [Google Scholar]
- Newcomb, JD; Ajrno, CT; Sanberg, CD; Sanberg, PR; Pennypacker, KR; Willing, AE. Timing of cord blood treatment after experimental stroke determines therapeutic efficacy. Cell Transplant 2006, 15, 213–223. [Google Scholar]
- Chen, SH; Chang, FM; Tsai, YC; Huang, KF; Lin, CL; Lin, MT. Resuscitation from experimental heatstroke by transplantation of human umbilical cord blood cells. Crit. Care Med 2005, 33, 1377–1383. [Google Scholar]
- Chen, SH; Chang, FM; Chang, HK; Chen, WC; Huang, KF; Lin, MT. Human umbilical cord blood-derived CD34+ cells cause attenuation of multiorgan dysfunction during experimental heatstroke. Shock 2007, 27, 663–671. [Google Scholar]
- Lu, D; Sanberg, PR; Mahmood, A; Li, Y; Wang, L; Sanchez-Ramos, J; Chopp, M. Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury. Cell Transplant 2002, 11, 275–281. [Google Scholar]
- Meier, C; Middelanis, J; Wasielewski, B; Neuhoff, S; Roth-Haerer, A; Gantert, M; Dinse, HR; Dermietzel, R; Jensen, A. Spastic paresis after perinatal brain damage in rats is reduced by human cord blood mononuclear cells. Pediatr. Res 2006, 59, 244–249. [Google Scholar]
- Xia, G; Hong, X; Chen, X; Lan, F; Zhang, G; Liao, L. Intracerebral transplantation of mesenchymal stem cells derived from human umbilical cord blood alleviates hypoxic ischemic brain injury in rat neonates. J. Perinat. Med 2010, 38, 215–221. [Google Scholar]
- Xiao, J; Nan, Z; Motooka, Y; Low, WC. Transplantation of a novel cell line population of umbilical cord blood stem cells ameliorates neurological deficits associated with ischemic brain injury. Stem Cells Dev 2005, 14, 722–733. [Google Scholar]
- Vendrame, M; Gemma, C; Pennypacker, KR; Bickford, PC; Davis Sanberg, C; Sanberg, PR; Willing, AE. Cord blood rescues stroke-induced changes in splenocyte phenotype and function. Exp. Neurol 2006, 199, 191–200. [Google Scholar]
- Hall, AA; Leonardo, CC; Collier, LA; Rowe, DD; Willing, AE; Pennypacker, KR. Delayed treatments for stroke influence neuronal death in rat organotypic slice cultures subjected to oxygen glucose deprivation. Neuroscience 2009, 164, 470–477. [Google Scholar]
- Ding, DC; Shyu, WC; Chiang, MF; Lin, SZ; Chang, YC; Wang, HJ; Su, CY; Li, H. Enhancement of neuroplasticity through upregulation of beta1-integrin in human umbilical cord-derived stromal cell implanted stroke model. Neurobiol. Dis 2007, 27, 339–353. [Google Scholar]
- Taguchi, A; Soma, T; Tanaka, H; Kanda, T; Nishimura, H; Yoshikawa, H; Tsukamoto, Y; Iso, H; Fujimori, Y; Stern, DM; et al. Administration of CD34 cells after stroke enhances neurogenesis via angiogenesis in a mouse model. J. Clin. Invest 2004, 114, 330–338. [Google Scholar]
- Chung, DJ; Choi, CB; Lee, SH; KangK, EH; Lee, JH; Hwang, SH; Han, H; Lee, JH; Choe, BY; Lee, SY; Kim, HY. Intraarterially delivered human umbilical cord blood-derived mesenchymal stem cells in canine cerebral ischemia. J. Neurosci. Res 2009, 87, 3554–3567. [Google Scholar]
- Arien-Zakay, H; Lecht, S; Bercu, MM; Tabakman, R; Kohen, R; Galski, H; Nagler, A; Lazarovici, P. Neuroprotection by cord blood neural progenitors involves antioxidants, neurotrophic and angiogenic factors. Exp. Neurol 2009, 216, 83–94. [Google Scholar]
- Vendrame, M; Gemma, C; de Mesquita, D; Collier, L; Bickford, PC; Sanberg, CD; Sanberg, PR; Pennypacker, KR; Willing, AE. Anti-inflammatory effects of human cord blood cells in a rat model of stroke. Stem Cells Dev 2005, 14, 595–604. [Google Scholar]
- Hau, S; Reich, DM; Scholz, M; Naumann, W; Emmrich, F; Kamprad, M; Boltze, J. Evidence for neuroprotective properties of human umbilical cord blood cells after neuronal hypoxia in vitro. BMC Neurosci 2008, 9, 30. [Google Scholar]
- Alexanian, AR; Maiman, DJ; Kurpad, SN; Gennarelli, TA. In vitro and in vivo characterization of neurally modified mesenchymal stem cells induced by epigenetic modifiers and neural stem cell environment. Stem Cells Dev 2008, 17, 1123–1130. [Google Scholar]
- Cho, SW; Gwak, SJ; Kang, SW; Bhang, SH; Won Song, KW; Yang, YS; Choi, CY; Kim, BS. Enhancement of angiogenic efficacy of human cord blood cell transplantation. Tissue Eng 2006, 12, 1651–1661. [Google Scholar]
- Martino, G; Pluchino, S. The therapeutic potential of neural stem cells. Nat. Rev. Neurosci 2006, 7, 395–406. [Google Scholar]
- Castrén, E. Neurotrophins as mediators of drug effects on mood, addiction, and neuroprotection. Mol. Neurobiol 2004, 29, 289–301. [Google Scholar]
- Hefti, F. Pharmacology of neurotrophic factors. Annu. Rev. Pharmacol. Toxicol 1997, 37, 239–267. [Google Scholar]
- Thoenen, H; Sendtner, M. Neurotrophins: From enthusiastic expectations through sobering experiences to rational therapeutic approaches. Nat. Neurosci 2002, 5, S1046–S1050. [Google Scholar]
- Poduslo, JF; Curran, GL. Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF. Brain Res. Mol.: Brain Res 1996, 36, 280–286. [Google Scholar]
- Goldstein, G; Toren, A; Nagler, A. Transplantation and other uses of human umbilical cord blood and stem cells. Curr. Pharm. Des 2007, 13, 1363–1373. [Google Scholar]
- Amantea, D; Nappi, G; Bernardi, G; Bagetta, G; Corasaniti, MT. Post-ischemic brain damage: Pathophysiology and role of inflammatory mediators. FEBS J 2009, 276, 13–26. [Google Scholar]
- Kriz, J; Lalancette-Hébert, M. Inflammation, plasticity and real-time imaging after cerebral ischemia. Acta Neuropathol 2009, 117, 497–509. [Google Scholar]
- Uyttenboogaart, M; Vroomen, PC; Stewart, RE; De, KJ; Luijckx, GJ. Safety of routine IV thrombolysis between 3 and 4.5 h after ischaemic stroke. J. Neurol. Sci 2007, 254, 28–32. [Google Scholar]
- Iihoshi, S; Honmou, O; Houkin, K; Hashi, K; Kocsis, JD. A therapeutic window for intravenous administration of autologous bone marrow after cerebral ischaemia in adult rats. Brain Res 2004, 1007, 1–9. [Google Scholar]
- Keimpema, E; Fokkens, MR; Nagy, Z; Agoston, V; Luiten, PG; Nyakas, C; Boddeke, HW; Copray, JC. Early transient presence of implanted bone marrow stem cells reduces lesion size after cerebral ischaemia in adult rats. Neuropathol. Appl. Neurobiol 2009, 35, 89–102. [Google Scholar]
- Chen, J; Chopp, M. Neurorestorative treatment of stroke: Cell and pharmacological approaches. NeuroRx 2006, 3, 466–473. [Google Scholar]
- Tang, Y; Yasuhara, T; Hara, K; Matsukawa, N; Maki, M; Yu, G; Xu, L; Hess, DC; Borlongan, CV. Transplantation of bone marrow-derived stem cells: A promising therapy for stroke. Cell Transplant 2007, 16, 159–169. [Google Scholar]
- Gladstone, DJ; Black, SE; Hakim, AM. Heart and stroke foundation of ontario centre of excellence in stroke recovery toward wisdom from failure: Lessons from neuroprotective stroke trials and new therapeutic directions. Stroke 2002, 33, 2123–2136. [Google Scholar]
- Low, CB; Liou, YC; Tang, BL. Neural differentiation and potential use of stem cells from the human umbilical cord for central nervous system transplantation therapy. J. Neurosci. Res 2008, 86, 1670–1679. [Google Scholar]
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Arien-Zakay, H.; Lecht, S.; Nagler, A.; Lazarovici, P. Human Umbilical Cord Blood Stem Cells: Rational for Use as a Neuroprotectant in Ischemic Brain Disease. Int. J. Mol. Sci. 2010, 11, 3513-3528. https://doi.org/10.3390/ijms11093513
Arien-Zakay H, Lecht S, Nagler A, Lazarovici P. Human Umbilical Cord Blood Stem Cells: Rational for Use as a Neuroprotectant in Ischemic Brain Disease. International Journal of Molecular Sciences. 2010; 11(9):3513-3528. https://doi.org/10.3390/ijms11093513
Chicago/Turabian StyleArien-Zakay, Hadar, Shimon Lecht, Arnon Nagler, and Philip Lazarovici. 2010. "Human Umbilical Cord Blood Stem Cells: Rational for Use as a Neuroprotectant in Ischemic Brain Disease" International Journal of Molecular Sciences 11, no. 9: 3513-3528. https://doi.org/10.3390/ijms11093513