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Int. J. Mol. Sci. 2010, 11(9), 3375-3386; doi:10.3390/ijms11093375
Article

Cigarette Smoke Affects ABCAl Expression via Liver X Receptor Nuclear Translocation in Human Keratinocytes

1
, 2
, 1
 and 1,3,*
Received: 2 September 2010; in revised form: 8 September 2010 / Accepted: 8 September 2010 / Published: 17 September 2010
(This article belongs to the Special Issue Advances in Molecular Toxicology)
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Abstract: Cutaneous tissue is the first barrier against outdoor insults. The outer most layer of the skin, the stratum corneum (SC), is formed by corneocytes embedded in a lipid matrix (cholesterol, ceramide and fatty acids). Therefore, the regulation of lipids and, in particular, of cholesterol homeostasis in the skin is of great importance. ABCA1 is a membrane transporter responsible for cholesterol efflux and plays a key role in maintaining cellular cholesterol levels. Among the many factors that have been associated with skin diseases, the environmental stressor cigarette smoke has been recently studied. In the present study, we demonstrate that ABCA1 expression in human cells (HaCaT) was increased (both mRNA and protein levels) after CS exposure. This effect was mediated by the inhibition of NFkB (aldehydes adducts formation) that allows the translocation of liver X receptor (LXR). These findings suggest that passive smoking may play a role in skin cholesterol levels and thus affect cutaneous tissues functions.
Keywords: ABCA1; keratinocyte; LXR; cigarette smoke; NFkB ABCA1; keratinocyte; LXR; cigarette smoke; NFkB
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sticozzi, C.; Pecorelli, A.; Belmonte, G.; Valacchi, G. Cigarette Smoke Affects ABCAl Expression via Liver X Receptor Nuclear Translocation in Human Keratinocytes. Int. J. Mol. Sci. 2010, 11, 3375-3386.

AMA Style

Sticozzi C, Pecorelli A, Belmonte G, Valacchi G. Cigarette Smoke Affects ABCAl Expression via Liver X Receptor Nuclear Translocation in Human Keratinocytes. International Journal of Molecular Sciences. 2010; 11(9):3375-3386.

Chicago/Turabian Style

Sticozzi, Claudia; Pecorelli, Alessandra; Belmonte, Giuseppe; Valacchi, Giuseppe. 2010. "Cigarette Smoke Affects ABCAl Expression via Liver X Receptor Nuclear Translocation in Human Keratinocytes." Int. J. Mol. Sci. 11, no. 9: 3375-3386.



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