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Int. J. Mol. Sci. 2010, 11(8), 2805-2820;

Integral Kinetic Model for Studying Quercetin Degradation and Oxidation as Affected by Cholesterol During Heating

Department of Food Science, Fu Jen University, Taipei 242, Taiwan
Author to whom correspondence should be addressed.
Received: 7 July 2010 / Revised: 20 July 2010 / Accepted: 27 July 2010 / Published: 29 July 2010
(This article belongs to the Section Physical Chemistry, Theoretical and Computational Chemistry)
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The degradation and oxidation of quercetin, as affected by cholesterol during heating at 150 °C, was kinetically studied using non-linear regression models. Both TLC and HPLC were used to monitor the changes of quercetin, cholesterol and cholesterol oxidation products (COPs) during heating. The formation of COPs, including triol, 7-keto, 7a-OH and 7b-OH, was completely inhibited during the initial 30 minute heating period in the presence of 0.02% quercetin, accompanied by reduction in cholesterol peroxidation and degradation. However, the quercetin degradation or oxidation proceeded fast, with the rate constants (h-1) in the presence of nitrogen, oxygen and the combination of oxygen and cholesterol being 0.253, 0.868 and 7.17, respectively. When cholesterol and quercetin were heated together, the rate constants (h-1) of cholesterol peroxidation, epoxidation and degradation were 1.8 ´ 10-4, 0.016 and 0.19, respectively. The correlation coefficients (r2) for all the oxidative and degradation reactions ranged from 0.82-0.99. The kinetic models developed in this study may be used to predict the degradation and oxidation of quercetin as affected by cholesterol during heating. View Full-Text
Keywords: quercetin; cholesterol oxidation; kinetic study quercetin; cholesterol oxidation; kinetic study

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Chien, J.-T.; Hsu, D.-J.; Inbaraj, B.S.; Chen, B.-H. Integral Kinetic Model for Studying Quercetin Degradation and Oxidation as Affected by Cholesterol During Heating. Int. J. Mol. Sci. 2010, 11, 2805-2820.

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