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Int. J. Mol. Sci. 2010, 11(7), 2746-2758; doi:10.3390/ijms11072746

Article

Anti-Allergic Activity of a Platycodon Root Ethanol Extract

You-Chang Oh¹ , Ok-Hwa Kang¹ , Jang-Gi Choi¹ , Young-Seob Lee¹ , Obiang-Obounou Brice¹ , Hyun Ju Jung¹ , Seung-Heon Hong¹ , Young-Mi Lee¹ , Dong-Won Shin² , Yeong-Shik Kim³  and Dong-Yeul Kwon^1,*

¹ College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Iksan 570-749, Korea ² Department of Oriental Medicine Resources, Sunchon National University, Jeonnam 540-742, Korea ³ Natural Products Research Institute College of Pharmacy, Seoul National University, Seoul 151-742, Korea

* Author to whom correspondence should be addressed.

Received: 21 May 2010; in revised form: 30 June 2010 / Accepted: 6 July 2010 / Published: 16 July 2010

(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)

Download PDF Full-Text [328 KB, uploaded 16 July 2010 12:01 CEST]

Abstract: Platycodon grandiflorum (Campanulaceae) is used as traditional medicine in Asian countries. In Korean traditional medicine, Platycodon root has been widely used since ancient times as a traditional drug to treat cold, cough and asthma. However, its effects on bone marrow-derived mast cell (BMMC)-mediated allergy and inflammation mechanisms remain unknown. In this study, the biological effect of Platycodon root ethanol extract (PE) was evaluated in BMMC after induction of allergic mediators by phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 (A23187) stimulation. The effect of PE on the production of several allergic mediators, such as interleukin-6 (IL-6), prostaglandin D₂ (PGD₂), leukotriene C₄ (LTC₄), β-Hexosaminidase (β-Hex) and cyclooxygenase-2 (COX-2) protein, was investigated. The results demonstrate that PE inhibits PMA + A23187 induced production of IL-6, PGD₂, LTC₄, β-Hexosaminidase and COX-2 protein. Taken together, these results indicate that PE has the potential for use in the treatment of allergy.

Keywords: antiallergy; Platycodon root; bone marrow-derived mast cell; prostaglandin D2; leukotriene C4; cyclooxygenase-2

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