Next Article in Journal
Advances Towards Synthetic Machines at the Molecular and Nanoscale Level
Previous Article in Journal
Neural Membrane Signaling Platforms
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2010, 11(6), 2443-2452; doi:10.3390/ijms11062443

Effect of Sodium Fluoride Ingestion on Malondialdehyde Concentration and the Activity of Antioxidant Enzymes in Rat Erythrocytes

1
Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Ex-Hacienda de la Concepción, Tilcuautla, 42080 Pachuca de Soto, Hgo, Mexico
2
Laboratorio de Bioquímica y Medicina Experimental, División de Investigación Biomédica, Centro Médico Nacional 20 de Noviembre, ISSSTE, Mexico, D.F., Mexico
3
Laboratorio de Medicina Genómica, División de Medicina Genómica, Centro Médico Nacional 20 de Noviembre, ISSSTE, Mexico, D.F., Mexico
4
Facultad de Odontologia, Universidad Nacional Autónoma de México (UNAM), Mexico, D.F., Mexico
*
Author to whom correspondence should be addressed.
Received: 27 April 2010 / Revised: 2 June 2010 / Accepted: 2 June 2010 / Published: 11 June 2010
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
View Full-Text   |   Download PDF [112 KB, uploaded 19 June 2014]

Abstract

Fluoride intoxication has been shown to produce diverse deleterious metabolic alterations within the cell. To determine the effects of sodium fluoride (NaF) treatment on malondialdehyde (MDA) levels and on the activity of antioxidant enzymes in rat erythrocytes, Male Wistar rats were treated with 50 ppm of NaF or were untreated as controls. Erythrocytes were obtained from rats sacrificed weekly for up to eight weeks and the concentration of MDA in erythrocyte membrane was determined. In addition, the activity of the enzymes superoxide, dismutase, catalase, and glutathione peroxidase were determined. Treatment with NaF produces an increase in the concentration of malondialdehyde in the erythrocyte membrane only after the eight weeks of treatment. On the other hand, antioxidant enzyme activity was observed to increase after the fourth week of NaF treatment. In conclusion, intake of NaF produces alterations in the erythrocyte of the male rat, which indicates induction of oxidative stress. View Full-Text
Keywords: antioxidant enzymes; erythrocyte; oxidative stress; sodium fluoride; rat antioxidant enzymes; erythrocyte; oxidative stress; sodium fluoride; rat
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Morales-González, J.A.; Gutiérrez-Salinas, J.; García-Ortiz, L.; Del Carmen Chima-Galán, M.; Madrigal-Santillán, E.; Esquivel-Soto, J.; Esquivel-Chirino, C.; García-Luna y González-Rubio, M. Effect of Sodium Fluoride Ingestion on Malondialdehyde Concentration and the Activity of Antioxidant Enzymes in Rat Erythrocytes. Int. J. Mol. Sci. 2010, 11, 2443-2452.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top