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Int. J. Mol. Sci. 2010, 11(6), 2281-2290; doi:10.3390/ijms11062281
Article

Serum Concentrations of TNF α and Its Soluble Receptors in Patients with Adrenal Tumors Treated by Surgery

1,* , 1, 2, 2, 2 and 3
1 Department of Clinical Endocrinology, First Chair of Endocrinology, Medical University of Lodz, Sterlinga1/3, 91-425 Lodz, Poland 2 Department of Endocrine and General Surgery, First Chair of Endocrinology, Pabianicka 62, Medical University of Lodz, 93-513 Lodz, Poland 3 Department of Immunoendocrinology, First Chair of Endocrinology, Medical University of Lodz, Sterlinga1/3, 91-425 Lodz, Poland
* Author to whom correspondence should be addressed.
Received: 29 April 2010 / Accepted: 21 May 2010 / Published: 26 May 2010
(This article belongs to the Special Issue Biomarkers)
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Abstract

The peripheral blood levels of TNF α and its soluble receptors were studied in 39 patients with malignant and benign adrenal tumors treated by adrenalectomy. The concentrations of TNF α were significantly elevated in patients with malignant tumors of the adrenal cortex and in patients with Conn's syndrome compared to control. In patients with non-functioning adenomas and pheochromocytomas, TNF α levels were similar to those detected in the control. In subjects with myelolipomas, the serum concentration of TNF α was lower compared to the control. After adrenalectomy, the levels of TNF α were decreased in patients with malignant tumors and in patients with Conn's syndrome, non-functioniong adenomas and pheochromocytomas compared to the concentration before surgery. The serum concentrations of soluble receptors of TNF α did not differ among different patient groups and compared to the control. After adrenalectomy, the blood concentrations of TNF α R1 and TNF α R2 were decreased in patients with Conn's syndrome. However, to confirm practicality of the evaluation of TNF α and its soluble receptors in differential diagnosis in patients with adrenal tumors, a larger study group is needed.
Keywords: adrenal tumors; TNF α; TNF α R1; TNF α R2; adrenalectomy adrenal tumors; TNF α; TNF α R1; TNF α R2; adrenalectomy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Komorowski, J.; Jurczynska, J.; Stepien, T.; Kolomecki, K.; Kuzdak, K.; Stepien, H. Serum Concentrations of TNF α and Its Soluble Receptors in Patients with Adrenal Tumors Treated by Surgery. Int. J. Mol. Sci. 2010, 11, 2281-2290.

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