Abstract: The peripheral blood levels of TNF α and its soluble receptors were studied in 39 patients with malignant and benign adrenal tumors treated by adrenalectomy. The concentrations of TNF α were significantly elevated in patients with malignant tumors of the adrenal cortex and in patients with Conn's syndrome compared to control. In patients with non-functioning adenomas and pheochromocytomas, TNF α levels were similar to those detected in the control. In subjects with myelolipomas, the serum concentration of TNF α was lower compared to the control. After adrenalectomy, the levels of TNF α were decreased in patients with malignant tumors and in patients with Conn's syndrome, non-functioniong adenomas and pheochromocytomas compared to the concentration before surgery. The serum concentrations of soluble receptors of TNF α did not differ among different patient groups and compared to the control. After adrenalectomy, the blood concentrations of TNF α R1 and TNF α R2 were decreased in patients with Conn's syndrome. However, to confirm practicality of the evaluation of TNF α and its soluble receptors in differential diagnosis in patients with adrenal tumors, a larger study group is needed.
Keywords: adrenal tumors; TNF α; TNF α R1; TNF α R2; adrenalectomy
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Komorowski, J.; Jurczynska, J.; Stepien, T.; Kolomecki, K.; Kuzdak, K.; Stepien, H. Serum Concentrations of TNF α and Its Soluble Receptors in Patients with Adrenal Tumors Treated by Surgery. Int. J. Mol. Sci. 2010, 11, 2281-2290.
Komorowski J, Jurczynska J, Stepien T, Kolomecki K, Kuzdak K, Stepien H. Serum Concentrations of TNF α and Its Soluble Receptors in Patients with Adrenal Tumors Treated by Surgery. International Journal of Molecular Sciences. 2010; 11(6):2281-2290.
Komorowski, Jan; Jurczynska, Jolanta; Stepien, Tomasz; Kolomecki, Krzysztof; Kuzdak, Krzysztof; Stepien, Henryk. 2010. "Serum Concentrations of TNF α and Its Soluble Receptors in Patients with Adrenal Tumors Treated by Surgery." Int. J. Mol. Sci. 11, no. 6: 2281-2290.