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Int. J. Mol. Sci. 2010, 11(4), 1509-1526; doi:10.3390/ijms11041509
Review

Oxidative Stress, Molecular Inflammation and Sarcopenia

1,2
 and
1,*
Received: 5 March 2010 / Revised: 12 March 2010 / Accepted: 6 April 2010 / Published: 12 April 2010
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Sarcopenia is the decline of muscle mass and strength with age. Evidence suggests that oxidative stress and molecular inflammation play important roles in age-related muscle atrophy. The two factors may interfere with the balance between protein synthesis and breakdown, cause mitochondrial dysfunction, and induce apoptosis. The purpose of this review is to discuss some of the major signaling pathways that are activated or inactivated during the oxidative stress and molecular inflammation seen in aged skeletal muscle. Combined interventions that may be required to reverse sarcopenia, such as exercise, caloric restriction, and nutrition, will also be discussed.
Keywords: oxidative stress; chronic inflammation; signaling; sarcopenia; interventions oxidative stress; chronic inflammation; signaling; sarcopenia; interventions
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Meng, S.-J.; Yu, L.-J. Oxidative Stress, Molecular Inflammation and Sarcopenia. Int. J. Mol. Sci. 2010, 11, 1509-1526.

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