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Oxidative Stress, Molecular Inflammation and Sarcopenia
Institution of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
College of Health Science, Wuhan Institute of Physical Education, Wuhan 430079, China
* Author to whom correspondence should be addressed.
Received: 5 March 2010; in revised form: 12 March 2010 / Accepted: 6 April 2010 / Published: 12 April 2010
Abstract: Sarcopenia is the decline of muscle mass and strength with age. Evidence suggests that oxidative stress and molecular inflammation play important roles in age-related muscle atrophy. The two factors may interfere with the balance between protein synthesis and breakdown, cause mitochondrial dysfunction, and induce apoptosis. The purpose of this review is to discuss some of the major signaling pathways that are activated or inactivated during the oxidative stress and molecular inflammation seen in aged skeletal muscle. Combined interventions that may be required to reverse sarcopenia, such as exercise, caloric restriction, and nutrition, will also be discussed.
Keywords: oxidative stress; chronic inflammation; signaling; sarcopenia; interventions
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MDPI and ACS Style
Meng, S.-J.; Yu, L.-J. Oxidative Stress, Molecular Inflammation and Sarcopenia. Int. J. Mol. Sci. 2010, 11, 1509-1526.
Meng S-J, Yu L-J. Oxidative Stress, Molecular Inflammation and Sarcopenia. International Journal of Molecular Sciences. 2010; 11(4):1509-1526.
Meng, Si-Jin; Yu, Long-Jiang. 2010. "Oxidative Stress, Molecular Inflammation and Sarcopenia." Int. J. Mol. Sci. 11, no. 4: 1509-1526.