Int. J. Mol. Sci. 2010, 11(4), 1413-1422; doi:10.3390/ijms11041413
Article

In Vivo Study of the Effects of Peptide-Conjugated Near-Infrared Fluorescent Quantum Dots on the Tumorigenic and Lymphatic Metastatic Capacities of Squamous Cell Carcinoma Cell Line Tca8113 and U14

Zhi-Gang Li 1 , Kai Yang 1,* email, Yu-An Cao 1 , Gang Zheng 2 , De-Ping Sun 1 , Cheng Zhao 1  and Jia Yang 1
1 Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China 2 Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400013, China
* Author to whom correspondence should be addressed.
Received: 8 February 2010; in revised form: 18 March 2010 / Accepted: 21 March 2010 / Published: 31 March 2010
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract: Quantum dots (QDs) have great potential in non-invasive monitoring and imaging of tumor cells in vivo, but it is unknown if QDs affect their tumorigenesis and metastasis. Here, we applied peptide-conjugated near-infrared fluorescent QDs (NIRF-QDs) to label the squamous cell carcinoma cells Tca8113 and U14. We tested the proliferation and apoptotic capacities of both cells, and the capacity of cervical lymph node metastasis after tumorigenesis in U14 cells’. We find that QDs do not affect the tumor cells’ capacities to grow, proliferate, and metastasize. Our study provides critical data to support the application of NIRF-QDs in non-invasive monitoring and imaging of tumor cells in vivo.
Keywords: peptide; near-infrared fluorescence; quantum dots; tumor; growth; proliferation; apoptosis; metastasis

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MDPI and ACS Style

Li, Z.-G.; Yang, K.; Cao, Y.-A.; Zheng, G.; Sun, D.-P.; Zhao, C.; Yang, J. In Vivo Study of the Effects of Peptide-Conjugated Near-Infrared Fluorescent Quantum Dots on the Tumorigenic and Lymphatic Metastatic Capacities of Squamous Cell Carcinoma Cell Line Tca8113 and U14. Int. J. Mol. Sci. 2010, 11, 1413-1422.

AMA Style

Li Z-G, Yang K, Cao Y-A, Zheng G, Sun D-P, Zhao C, Yang J. In Vivo Study of the Effects of Peptide-Conjugated Near-Infrared Fluorescent Quantum Dots on the Tumorigenic and Lymphatic Metastatic Capacities of Squamous Cell Carcinoma Cell Line Tca8113 and U14. International Journal of Molecular Sciences. 2010; 11(4):1413-1422.

Chicago/Turabian Style

Li, Zhi-Gang; Yang, Kai; Cao, Yu-An; Zheng, Gang; Sun, De-Ping; Zhao, Cheng; Yang, Jia. 2010. "In Vivo Study of the Effects of Peptide-Conjugated Near-Infrared Fluorescent Quantum Dots on the Tumorigenic and Lymphatic Metastatic Capacities of Squamous Cell Carcinoma Cell Line Tca8113 and U14." Int. J. Mol. Sci. 11, no. 4: 1413-1422.

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