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Int. J. Mol. Sci. 2010, 11(4), 1413-1422; doi:10.3390/ijms11041413

In Vivo Study of the Effects of Peptide-Conjugated Near-Infrared Fluorescent Quantum Dots on the Tumorigenic and Lymphatic Metastatic Capacities of Squamous Cell Carcinoma Cell Line Tca8113 and U14

1
Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China
2
Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400013, China
*
Author to whom correspondence should be addressed.
Received: 8 February 2010 / Revised: 18 March 2010 / Accepted: 21 March 2010 / Published: 31 March 2010
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

Quantum dots (QDs) have great potential in non-invasive monitoring and imaging of tumor cells in vivo, but it is unknown if QDs affect their tumorigenesis and metastasis. Here, we applied peptide-conjugated near-infrared fluorescent QDs (NIRF-QDs) to label the squamous cell carcinoma cells Tca8113 and U14. We tested the proliferation and apoptotic capacities of both cells, and the capacity of cervical lymph node metastasis after tumorigenesis in U14 cells’. We find that QDs do not affect the tumor cells’ capacities to grow, proliferate, and metastasize. Our study provides critical data to support the application of NIRF-QDs in non-invasive monitoring and imaging of tumor cells in vivo.
Keywords: peptide; near-infrared fluorescence; quantum dots; tumor; growth; proliferation; apoptosis; metastasis peptide; near-infrared fluorescence; quantum dots; tumor; growth; proliferation; apoptosis; metastasis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Li, Z.-G.; Yang, K.; Cao, Y.-A.; Zheng, G.; Sun, D.-P.; Zhao, C.; Yang, J. In Vivo Study of the Effects of Peptide-Conjugated Near-Infrared Fluorescent Quantum Dots on the Tumorigenic and Lymphatic Metastatic Capacities of Squamous Cell Carcinoma Cell Line Tca8113 and U14. Int. J. Mol. Sci. 2010, 11, 1413-1422.

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