Next Article in Journal
Cytotoxic Effects of 2-Bromopropane on Embryonic Development in Mouse Blastocysts
Previous Article in Journal
Molecular Design and Functional Control of Novel Self-Oscillating Polymers
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2010, 11(2), 719-730;

Temporal and Spatial Regulation of miR-320 in the Uterus during Embryo Implantation in the Rat

Reproductive and Genetic Center, National Research Institute for Family Planning, Beijing 100081, China
Graduate School, Peking Union Medical College, Beijing 100005, China
Author to whom correspondence should be addressed.
Received: 2 December 2009 / Accepted: 10 February 2010 / Published: 11 February 2010
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
Full-Text   |   PDF [1442 KB, uploaded 19 June 2014]


The implantation process is complex, requiring reciprocal interactions between implantation-competent blastocysts and the receptive uterus. There were reports to show that some microRNAs (miRNAs) may play a key role during embryo implantation in mouse. However, the miR-320 expression profiles in the rat uterus during peri-implantation are unknown. In the present study, we found that the expression level of miR-320 was lower on day 5 of gestation (g.d. 5) in rats than g.d.3 and g.d.4 and restored gradually from g.d.6. MiR-320 was specifically localized in glandular and luminal epithelia and decidua. The expression of miR-320 was not significantly different in the pseudopregnant uterus and decreased in the uteri of rats subjected to activation of delayed implantation. Artificial decidualization and treatment with progesterone increased the miR-320 expression. Thus, miR-320 was differentially expressed in the rat uterus during implantation. The expression level was affected by active blastocysts and decidualization during the window of implantation. Steroid hormones, progesterone stimulated miR-320 expression. View Full-Text
Keywords: miR-320; embryo implantation; uterus; rat; hormone; pregnancy miR-320; embryo implantation; uterus; rat; hormone; pregnancy
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Xia, H.-F.; Jin, X.-H.; Song, P.-P.; Cui, Y.; Liu, C.-M.; Ma, X. Temporal and Spatial Regulation of miR-320 in the Uterus during Embryo Implantation in the Rat. Int. J. Mol. Sci. 2010, 11, 719-730.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top