Int. J. Mol. Sci. 2010, 11(2), 407-426; doi:10.3390/ijms11020407
Review

The Fibrillar Collagen Family

Received: 30 December 2009; in revised form: 22 January 2010 / Accepted: 23 January 2010 / Published: 28 January 2010
(This article belongs to the Special Issue Cladistic Analysis and Molecular Evolution)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Collagens, or more precisely collagen-based extracellular matrices, are often considered as a metazoan hallmark. Among the collagens, fibrillar collagens are present from sponges to humans, and are involved in the formation of the well-known striated fibrils. In this review we discuss the different steps in the evolution of this protein family, from the formation of an ancestral fibrillar collagen gene to the formation of different clades. Genomic data from the choanoflagellate (sister group of Metazoa) Monosiga brevicollis, and from diploblast animals, have suggested that the formation of an ancestral α chain occurred before the metazoan radiation. Phylogenetic studies have suggested an early emergence of the three clades that were first described in mammals. Hence the duplication events leading to the formation of the A, B and C clades occurred before the eumetazoan radiation. Another important event has been the two rounds of “whole genome duplication” leading to the amplification of fibrillar collagen gene numbers, and the importance of this diversification in developmental processes. We will also discuss some other aspects of fibrillar collagen evolution such as the development of the molecular mechanisms involved in the formation of procollagen molecules and of striated fibrils.
Keywords: fibrillar collagen; extracellular matrix; metazoan evolution
PDF Full-text Download PDF Full-Text [872 KB, uploaded 19 June 2014 02:52 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Exposito, J.-Y.; Valcourt, U.; Cluzel, C.; Lethias, C. The Fibrillar Collagen Family. Int. J. Mol. Sci. 2010, 11, 407-426.

AMA Style

Exposito J-Y, Valcourt U, Cluzel C, Lethias C. The Fibrillar Collagen Family. International Journal of Molecular Sciences. 2010; 11(2):407-426.

Chicago/Turabian Style

Exposito, Jean-Yves; Valcourt, Ulrich; Cluzel, Caroline; Lethias, Claire. 2010. "The Fibrillar Collagen Family." Int. J. Mol. Sci. 11, no. 2: 407-426.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert