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Applications of Chitin and Its Derivatives in Biological Medicine
Institute of Basic Medical Science, Yonsei University Wonju College of Medicine, Wonju 220-701, Korea
Department of Chemistry, Dong-Eui University, Busan 614-714, Korea
* Author to whom correspondence should be addressed.
Received: 1 November 2010; in revised form: 2 December 2010 / Accepted: 6 December 2010 / Published: 15 December 2010
Abstract: Chitin and its derivatives—as a potential resource as well as multiple functional substrates—have generated attractive interest in various fields such as biomedical, pharmaceutical, food and environmental industries, since the first isolation of chitin in 1811. Moreover, chitosan and its chitooligosaccharides (COS) are degraded products of chitin through enzymatic and acidic hydrolysis processes; and COS, in particular, is well suited for potential biological application, due to the biocompatibility and nontoxic nature of chitosan. In this review, we investigate the current bioactivities of chitin derivatives, which are all correlated with their biomedical properties. Several new and cutting edge insights here may provide a molecular basis for the mechanism of chitin, and hence may aid its use for medical and pharmaceutical applications.
Keywords: chitin; chitosan; antioxidant; anticancer; anti-inflammatory; drug delivery
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Park, B.K.; Kim, M.-M. Applications of Chitin and Its Derivatives in Biological Medicine. Int. J. Mol. Sci. 2010, 11, 5152-5164.
Park BK, Kim M-M. Applications of Chitin and Its Derivatives in Biological Medicine. International Journal of Molecular Sciences. 2010; 11(12):5152-5164.
Park, Bae Keun; Kim, Moon-Moo. 2010. "Applications of Chitin and Its Derivatives in Biological Medicine." Int. J. Mol. Sci. 11, no. 12: 5152-5164.