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Int. J. Mol. Sci. 2010, 11(12), 4882-4890; doi:10.3390/ijms11124882

In Situ and in Vivo Study of Nasal Absorption of Paeonol in Rats

1,* , 1, 1, 1, 1 and 1
1 School of Chinese Materia Medica, Beijing University of Chinese Medicine, No.6, Zhonghuan South Road, Wangjing, Chaoyang district, Beijing 100102, China 2 Department of Chinese Pharmacy, Guiyang College of TCM, Guiyang, Guizhou 550002, China
* Author to whom correspondence should be addressed.
Received: 12 October 2010 / Revised: 10 November 2010 / Accepted: 10 November 2010 / Published: 26 November 2010
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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The objective of this work was to study the in situ and in vivo nasal absorption of paeonol. A novel single pass in situ nasal perfusion technique was applied to examine the rate and extent of nasal absorption of paeonol by rats. Various experimental conditions, such as perfusion rate, pH, osmotic pressure and drug concentration, were investigated. The in situ experiments showed that the nasal absorption of paeonol was not dependent on drug concentration, and fitted a first order process. The absorption rate constant, Ka, increased with an increase in perfusion speed. Paeonol was better absorbed in acidic solutions than in neutral or alkaline solutions. The value of Ka was higher in a hypertonic environment than under isotonic or hypotonic conditions. In vivo studies of paeonol absorption were carried out in rats and the pharmacokinetics parameters of intranasal (i.n.) and intragastric (i.g.) administration were compared with intravenous (i.v.) administration. The bioavailabilities of paeonol were 52.37% and 15.81% for i.n. and i.g, respectively, while Tmax values were 3.05 ± 1.46 min and 6.30 ± 0.70 min. MRT (Mean Residence Time) were 23.19 ± 6.46 min, 41.49 ± 2.96 min and 23.09 ± 5.88 min for i.n., i.g. and i.v. methods, respectively. The results demonstrate that paeonol could be absorbed promptly and thoroughly by i.n. administration in rats.
Keywords: paeonol; nasal absorption; in situ; single pass perfusion technique; pharmacokinetics paeonol; nasal absorption; in situ; single pass perfusion technique; pharmacokinetics
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chen, X.; Lu, Y.; Du, S.; Xu, B.; Wang, S.; Zhai, Y.; Song, X.; Li, P. In Situ and in Vivo Study of Nasal Absorption of Paeonol in Rats. Int. J. Mol. Sci. 2010, 11, 4882-4890.

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