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• Delobel, J
• Rubin, O
• Prudent, M
• Crettaz, D
• Tissot, J
• Lion, N
• [+] on Google Scholar
• Delobel, J
• Rubin, O
• Prudent, M
• Crettaz, D
• Tissot, J
• Lion, N
• [+] on PubMed
• Delobel, J
• Rubin, O
• Prudent, M
• Crettaz, D
• Tissot, J
• Lion, N

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Int. J. Mol. Sci. 2010, 11(11), 4601-4617; doi:10.3390/ijms11114601

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Biomarker Analysis of Stored Blood Products: Emphasis on Pre-Analytical Issues

Julien Delobel ^1,2 , Olivier Rubin ^1,2 , Michel Prudent ¹ , David Crettaz ¹ , Jean-Daniel Tissot ^1,*  and Niels Lion ¹

¹ Service Régional Vaudois de Transfusion Sanguine, route de la Corniche 2, CH-1066 Epalinges, Switzerland ² Faculté de Biologie et Médecine, Université de Lausanne, rue du Bugnon 21, CH-1011 Lausanne, Switzerland

* Author to whom correspondence should be addressed.

Received: 18 October 2010; in revised form: 10 November 2010 / Accepted: 14 November 2010 / Published: 17 November 2010

(This article belongs to the Special Issue Biomarkers)

Download PDF Full-Text [217 KB, uploaded 17 November 2010 11:58 CET]

Abstract: Millions of blood products are transfused every year; many lives are thus directly concerned by transfusion. The three main labile blood products used in transfusion are erythrocyte concentrates, platelet concentrates and fresh frozen plasma. Each of these products has to be stored according to its particular components. However, during storage, modifications or degradation of those components may occur, and are known as storage lesions. Thus, biomarker discovery of in vivo blood aging as well as in vitro labile blood products storage lesions is of high interest for the transfusion medicine community. Pre-analytical issues are of major importance in analyzing the various blood products during storage conditions as well as according to various protocols that are currently used in blood banks for their preparations. This paper will review key elements that have to be taken into account in the context of proteomic-based biomarker discovery applied to blood banking.

Keywords: labile blood products; aging and storage lesions; biomarkers; pre-analytics; proteomics

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