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Int. J. Mol. Sci. 2010, 11(10), 4140-4148; doi:10.3390/ijms11104140
Article

In Vivo Biocompatibility Study of Electrospun Chitosan Microfiber for Tissue Engineering

1
, 1
, 2
, 1
, 1
, 1
, 1
, 2
, 3
, 4
 and 1,*
1 Department of Molecular Science and Technology, Ajou University, Suwon, 443-749, Korea 2 Digital Dyeing & Finishing Tech, Korea Institute of Industrial Technology, Ansan, 426-791, Korea 3 Department of Biomedical Sciences, College of Medicine, Catholic University, Seoul, 137-701, Korea 4 Laboratory of Tissue Engineering, Korea Institute of Radiological and Medical Sciences, Seoul, 139-706, Korea
* Author to whom correspondence should be addressed.
Received: 28 September 2010 / Revised: 19 October 2010 / Accepted: 19 October 2010 / Published: 25 October 2010
(This article belongs to the Special Issue Chitins)
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Abstract

In this work, we examined the biocompatibility of electrospun chitosan microfibers as a scaffold. The chitosan microfibers showed a three-dimensional pore structure by SEM. The chitosan microfibers supported attachment and viability of rat muscle-derived stem cells (rMDSCs). Subcutaneous implantation of the chitosan microfibers demonstrated that implantation of rMDSCs containing chitosan microfibers induced lower host tissue responses with decreased macrophage accumulation than did the chitosan microfibers alone, probably due to the immunosuppression of the transplanted rMDSCs. Our results collectively show that chitosan microfibers could serve as a biocompatible in vivo scaffold for rMDSCs in rats.
Keywords: electrospun; chitosan; microfibers; scaffold; stem cell electrospun; chitosan; microfibers; scaffold; stem cell
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kang, Y.M.; Lee, B.N.; Ko, J.H.; Kim, G.H.; Kang, K.N.; Kim, D.Y.; Kim, J.H.; Park, Y.H.; Chun, H.J.; Kim, C.H.; Kim, M.S. In Vivo Biocompatibility Study of Electrospun Chitosan Microfiber for Tissue Engineering. Int. J. Mol. Sci. 2010, 11, 4140-4148.

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