Next Article in Journal
Lipid Based Therapy for Ulcerative Colitis—Modulation of Intestinal Mucus Membrane Phospholipids as a Tool to Influence Inflammation
Next Article in Special Issue
In vitro Evaluation of Acyclovir/Chitosan Floating Systems
Previous Article in Journal
On Heisenberg Uncertainty Relationship, Its Extension, and the Quantum Issue of Wave-Particle Duality
Previous Article in Special Issue
Fabrication of Chitosan/Silk Fibroin Composite Nanofibers for Wound-dressing Applications
Int. J. Mol. Sci. 2010, 11(10), 4140-4148; doi:10.3390/ijms11104140

In Vivo Biocompatibility Study of Electrospun Chitosan Microfiber for Tissue Engineering

, 1
, 2
, 1
, 1
, 1
, 1
, 2
, 3
, 4
 and 1,*
1 Department of Molecular Science and Technology, Ajou University, Suwon, 443-749, Korea 2 Digital Dyeing & Finishing Tech, Korea Institute of Industrial Technology, Ansan, 426-791, Korea 3 Department of Biomedical Sciences, College of Medicine, Catholic University, Seoul, 137-701, Korea 4 Laboratory of Tissue Engineering, Korea Institute of Radiological and Medical Sciences, Seoul, 139-706, Korea
* Author to whom correspondence should be addressed.
Received: 28 September 2010 / Revised: 19 October 2010 / Accepted: 19 October 2010 / Published: 25 October 2010
(This article belongs to the Special Issue Chitins)
View Full-Text   |   Download PDF [498 KB, uploaded 19 June 2014]   |   Browse Figures


In this work, we examined the biocompatibility of electrospun chitosan microfibers as a scaffold. The chitosan microfibers showed a three-dimensional pore structure by SEM. The chitosan microfibers supported attachment and viability of rat muscle-derived stem cells (rMDSCs). Subcutaneous implantation of the chitosan microfibers demonstrated that implantation of rMDSCs containing chitosan microfibers induced lower host tissue responses with decreased macrophage accumulation than did the chitosan microfibers alone, probably due to the immunosuppression of the transplanted rMDSCs. Our results collectively show that chitosan microfibers could serve as a biocompatible in vivo scaffold for rMDSCs in rats.
Keywords: electrospun; chitosan; microfibers; scaffold; stem cell electrospun; chitosan; microfibers; scaffold; stem cell
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |

MDPI and ACS Style

Kang, Y.M.; Lee, B.N.; Ko, J.H.; Kim, G.H.; Kang, K.N.; Kim, D.Y.; Kim, J.H.; Park, Y.H.; Chun, H.J.; Kim, C.H.; Kim, M.S. In Vivo Biocompatibility Study of Electrospun Chitosan Microfiber for Tissue Engineering. Int. J. Mol. Sci. 2010, 11, 4140-4148.

View more citation formats

Related Articles

Article Metrics


Citing Articles

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert