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In Vivo Biocompatibility Study of Electrospun Chitosan Microfiber for Tissue Engineering
Department of Molecular Science and Technology, Ajou University, Suwon, 443-749, Korea
Digital Dyeing & Finishing Tech, Korea Institute of Industrial Technology, Ansan, 426-791, Korea
Department of Biomedical Sciences, College of Medicine, Catholic University, Seoul, 137-701, Korea
Laboratory of Tissue Engineering, Korea Institute of Radiological and Medical Sciences, Seoul, 139-706, Korea
* Author to whom correspondence should be addressed.
Received: 28 September 2010; in revised form: 19 October 2010 / Accepted: 19 October 2010 / Published: 25 October 2010
(This article belongs to the Special Issue Chitins
Abstract: In this work, we examined the biocompatibility of electrospun chitosan microfibers as a scaffold. The chitosan microfibers showed a three-dimensional pore structure by SEM. The chitosan microfibers supported attachment and viability of rat muscle-derived stem cells (rMDSCs). Subcutaneous implantation of the chitosan microfibers demonstrated that implantation of rMDSCs containing chitosan microfibers induced lower host tissue responses with decreased macrophage accumulation than did the chitosan microfibers alone, probably due to the immunosuppression of the transplanted rMDSCs. Our results collectively show that chitosan microfibers could serve as a biocompatible in vivo scaffold for rMDSCs in rats.
Keywords: electrospun; chitosan; microfibers; scaffold; stem cell
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MDPI and ACS Style
Kang, Y.M.; Lee, B.N.; Ko, J.H.; Kim, G.H.; Kang, K.N.; Kim, D.Y.; Kim, J.H.; Park, Y.H.; Chun, H.J.; Kim, C.H.; Kim, M.S. In Vivo Biocompatibility Study of Electrospun Chitosan Microfiber for Tissue Engineering. Int. J. Mol. Sci. 2010, 11, 4140-4148.
Kang YM, Lee BN, Ko JH, Kim GH, Kang KN, Kim DY, Kim JH, Park YH, Chun HJ, Kim CH, Kim MS. In Vivo Biocompatibility Study of Electrospun Chitosan Microfiber for Tissue Engineering. International Journal of Molecular Sciences. 2010; 11(10):4140-4148.
Kang, Yun Mi; Lee, Bit Na; Ko, Jae Hoon; Kim, Gyeong Hae; Kang, Kkot Nim; Kim, Da Yeon; Kim, Jae Ho; Park, Young Hwan; Chun, Heung Jae; Kim, Chun Ho; Kim, Moon Suk. 2010. "In Vivo Biocompatibility Study of Electrospun Chitosan Microfiber for Tissue Engineering." Int. J. Mol. Sci. 11, no. 10: 4140-4148.