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Int. J. Mol. Sci. 2010, 11(10), 3846-3866; doi:10.3390/ijms11103846
Review

Recent Advances in Fragment-Based QSAR and Multi-Dimensional QSAR Methods

1
 and 1,2,3,*
Received: 27 August 2010; in revised form: 17 September 2010 / Accepted: 23 September 2010 / Published: 8 October 2010
(This article belongs to the Special Issue Recent Advances in QSAR/QSPR Theory)
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Abstract: This paper provides an overview of recently developed two dimensional (2D) fragment-based QSAR methods as well as other multi-dimensional approaches. In particular, we present recent fragment-based QSAR methods such as fragment-similarity-based QSAR (FS-QSAR), fragment-based QSAR (FB-QSAR), Hologram QSAR (HQSAR), and top priority fragment QSAR in addition to 3D- and nD-QSAR methods such as comparative molecular field analysis (CoMFA), comparative molecular similarity analysis (CoMSIA), Topomer CoMFA, self-organizing molecular field analysis (SOMFA), comparative molecular moment analysis (COMMA), autocorrelation of molecular surfaces properties (AMSP), weighted holistic invariant molecular (WHIM) descriptor-based QSAR (WHIM), grid-independent descriptors (GRIND)-based QSAR, 4D-QSAR, 5D-QSAR and 6D-QSAR methods.
Keywords: QSAR; fragment similarity based; fragment-based; 2D-QSAR; 3D-QSAR; nD-QSAR QSAR; fragment similarity based; fragment-based; 2D-QSAR; 3D-QSAR; nD-QSAR
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Myint, K.Z.; Xie, X.-Q. Recent Advances in Fragment-Based QSAR and Multi-Dimensional QSAR Methods. Int. J. Mol. Sci. 2010, 11, 3846-3866.

AMA Style

Myint KZ, Xie X-Q. Recent Advances in Fragment-Based QSAR and Multi-Dimensional QSAR Methods. International Journal of Molecular Sciences. 2010; 11(10):3846-3866.

Chicago/Turabian Style

Myint, Kyaw Zeyar; Xie, Xiang-Qun. 2010. "Recent Advances in Fragment-Based QSAR and Multi-Dimensional QSAR Methods." Int. J. Mol. Sci. 11, no. 10: 3846-3866.


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