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Recent Advances in Fragment-Based QSAR and Multi-Dimensional QSAR Methods
Int. J. Mol. Sci. 2010, 11(10), 3867-3884; doi:10.3390/ijms11103867

Three-Dimensional Models of the Oligomeric Human Asialoglycoprotein Receptor (ASGP-R)

Received: 12 August 2010 / Revised: 27 September 2010 / Accepted: 27 September 2010 / Published: 11 October 2010
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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The work presented here is aimed at suggesting plausible hypotheses for functional oligomeric forms of the human asialoglycoprotein receptor (ASGP-R), by applying a combination of different computational techniques. The functional ASGP-R is a hetero-oligomer, that comprises of several subunits of two different kinds (H1 and H2), which are highly homologous. Its stoichiometry is still unknown. An articulated step-wise modeling protocol was used in order to build the receptor model in a minimal oligomeric form, necessary for it to bind multi-antennary carbohydrate ligands. The ultimate target of the study is to contribute to increasing the knowledge of interactions between the human ASGP-R and carbohydrate ligands, at the molecular level, pertinent to applications in the field of hepatic tissue engineering.
Keywords: ASGP-R; oligomeric form; antennary carbohydratic ligands ASGP-R; oligomeric form; antennary carbohydratic ligands
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Massarelli, I.; Chiellini, F.; Chiellini, E.; Bianucci, A.M. Three-Dimensional Models of the Oligomeric Human Asialoglycoprotein Receptor (ASGP-R). Int. J. Mol. Sci. 2010, 11, 3867-3884.

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