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Int. J. Mol. Sci. 2010, 11(10), 3867-3884; doi:10.3390/ijms11103867

Three-Dimensional Models of the Oligomeric Human Asialoglycoprotein Receptor (ASGP-R)

1
UdR INSTM, Department of Pharmaceutical Sciences, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy
2
Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab)-UdR INSTM, Department of Chemistry & Industrial Chemistry, University of Pisa, Via Vecchia Livornese 1291, 56010 S. Piero a Grado, Pisa, Italy
3
Department of Pharmaceutical Sciences, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy
*
Author to whom correspondence should be addressed.
Received: 12 August 2010 / Revised: 27 September 2010 / Accepted: 27 September 2010 / Published: 11 October 2010
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The work presented here is aimed at suggesting plausible hypotheses for functional oligomeric forms of the human asialoglycoprotein receptor (ASGP-R), by applying a combination of different computational techniques. The functional ASGP-R is a hetero-oligomer, that comprises of several subunits of two different kinds (H1 and H2), which are highly homologous. Its stoichiometry is still unknown. An articulated step-wise modeling protocol was used in order to build the receptor model in a minimal oligomeric form, necessary for it to bind multi-antennary carbohydrate ligands. The ultimate target of the study is to contribute to increasing the knowledge of interactions between the human ASGP-R and carbohydrate ligands, at the molecular level, pertinent to applications in the field of hepatic tissue engineering.
Keywords: ASGP-R; oligomeric form; antennary carbohydratic ligands ASGP-R; oligomeric form; antennary carbohydratic ligands
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Massarelli, I.; Chiellini, F.; Chiellini, E.; Bianucci, A.M. Three-Dimensional Models of the Oligomeric Human Asialoglycoprotein Receptor (ASGP-R). Int. J. Mol. Sci. 2010, 11, 3867-3884.

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