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The Reversal of Drug-Resistance in Tumors Using a Drug-Carrying Nanoparticular System
College of Pharmacy, Chung-Ang University, 221 Heukseok dong, Seoul 155-756, Korea
Division of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Korea
Department of Diagnostic Radiology, Yonsei University College of Medicine, Seodaemun-ku Shinchon-dong 134, Seoul, 120-752, Korea
College of Pharmacy, Pusan National University, Jangjun-dong, Geumjeong-gu, Busan 609-735, Korea
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 4 August 2009; Accepted: 26 August 2009 / Published: 31 August 2009
Abstract: Medical applications of nanoparticular systems have attracted considerable attention because of their potential use in therapeutic targeting of disease tissues and their lower level of toxicity against healthy tissue, relative to traditional pharmaceutical drugs. The use of nanoparticular systems has been shown to overcome the limitations of most anticancer drugs in clinical applications. In particular, the improved performance of smarted nanoparticular system for solving the drug resistance problems that typically interrupt tumor treatment has provided a promising strategy for successful tumor chemotherapy. This review highlights recent studies that have examined the therapeutic effect of nanoparticular systems on drug-resistant tumors and presents insight on how they work.
Keywords: multi-drug resistance; nanoparticle; tumor treatment; drug delivery system
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Oh, K.T.; Baik, H.J.; Lee, A.H.; Oh, Y.T.; Youn, Y.S.; Lee, E.S. The Reversal of Drug-Resistance in Tumors Using a Drug-Carrying Nanoparticular System. Int. J. Mol. Sci. 2009, 10, 3776-3792.
Oh KT, Baik HJ, Lee AH, Oh YT, Youn YS, Lee ES. The Reversal of Drug-Resistance in Tumors Using a Drug-Carrying Nanoparticular System. International Journal of Molecular Sciences. 2009; 10(9):3776-3792.
Oh, Kyung T.; Baik, Hye J.; Lee, A H.; Oh, Young T.; Youn, Yu S.; Lee, Eun S. 2009. "The Reversal of Drug-Resistance in Tumors Using a Drug-Carrying Nanoparticular System." Int. J. Mol. Sci. 10, no. 9: 3776-3792.