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Int. J. Mol. Sci. 2009, 10(8), 3616-3634; doi:10.3390/ijms10083616

Effect of the Polysaccharide Extract from the Edible Mushroom Pleurotus ostreatus against Infectious Bursal Disease Virus

1
Laboratory of Plant Biotechnology, Biology Department, West University of Timişoara, Pestalozzi Str. 16, RO-300115, Romania
2
Laboratory of Computational and Structural Physical Chemistry, Chemistry Department, West University of Timişoara, Pestalozzi Str. 16, RO-300115, Romania
3
Laboratory of Virology, National Agency for Sanitary Veterinary and Food Safety, Timişoara Branch, Martir Caceu Str. 4, Timişoara, Romania
*
Authors to whom correspondence should be addressed.
Received: 2 July 2009 / Revised: 11 August 2009 / Accepted: 12 August 2009 / Published: 18 August 2009
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

The polysaccharide-containing extracellular fractions (EFs) of the edible mushroom Pleurotus ostreatus have immunomodulating effects. Being aware of these therapeutic effects of mushroom extracts, we have investigated the synergistic relations between these extracts and BIAVAC and BIAROMVAC vaccines. These vaccines target the stimulation of the immune system in commercial poultry, which are extremely vulnerable in the first days of their lives. By administrating EF with polysaccharides from P. ostreatus to unvaccinated broilers we have noticed slow stimulation of maternal antibodies against infectious bursal disease (IBD) starting from four weeks post hatching. For the broilers vaccinated with BIAVAC and BIAROMVAC vaccines a low to almost complete lack of IBD maternal antibodies has been recorded. By adding 5% and 15% EF in the water intake, as compared to the reaction of the immune system in the previous experiment, the level of IBD antibodies was increased. This has led us to believe that by using this combination of BIAVAC and BIAROMVAC vaccine and EF from P. ostreatus we can obtain good results in stimulating the production of IBD antibodies in the period of the chicken first days of life, which are critical to broilers’ survival. This can be rationalized by the newly proposed reactivity biological activity (ReBiAc) principles by examining the parabolic relationship between EF administration and recorded biological activity. View Full-Text
Keywords: extracellular fraction; Gumboro disease; BIAVAC & BIAROMVAC vaccines; ReBiAc principles extracellular fraction; Gumboro disease; BIAVAC & BIAROMVAC vaccines; ReBiAc principles
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Selegean, M.; Putz, M.V.; Rugea, T. Effect of the Polysaccharide Extract from the Edible Mushroom Pleurotus ostreatus against Infectious Bursal Disease Virus. Int. J. Mol. Sci. 2009, 10, 3616-3634.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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