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Int. J. Mol. Sci. 2009, 10(7), 2972-2985; doi:10.3390/ijms10072972
Review

Hyaluronan Benzyl Ester as a Scaffold for Tissue Engineering

1
, 2
, 2, 2
 and 2,*
Received: 8 May 2009; in revised form: 6 June 2009 / Accepted: 22 June 2009 / Published: 3 July 2009
(This article belongs to the Special Issue Biocompatibility of Materials)
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Abstract: Tissue engineering is a multidisciplinary field focused on in vitro reconstruction of mammalian tissues. In order to allow a similar three-dimensional organization of in vitro cultured cells, biocompatible scaffolds are needed. This need has provided immense momentum for research on “smart scaffolds” for use in cell culture. One of the most promising materials for tissue engineering and regenerative medicine is a hyaluronan derivative: a benzyl ester of hyaluronan (HYAFF®). HYAFF® can be processed to obtain several types of devices such as tubes, membranes, non-woven fabrics, gauzes, and sponges. All these scaffolds are highly biocompatible. In the human body they do not elicit any adverse reactions and are resorbed by the host tissues. Human hepatocytes, dermal fibroblasts and keratinocytes, chondrocytes, Schwann cells, bone marrow derived mesenchymal stem cells and adipose tissue derived mesenchymal stem cells have been successfully cultured in these meshes. The same scaffolds, in tube meshes, has been applied for vascular tissue engineering that has emerged as a promising technology for the design of an ideal, responsive, living conduit with properties similar to that of native tissue.
Keywords: HYAFF; hyaluronan; tissue engineering HYAFF; hyaluronan; tissue engineering
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Vindigni, V.; Cortivo, R.; Iacobellis, L.; Abatangelo, G.; Zavan, B. Hyaluronan Benzyl Ester as a Scaffold for Tissue Engineering. Int. J. Mol. Sci. 2009, 10, 2972-2985.

AMA Style

Vindigni V, Cortivo R, Iacobellis L, Abatangelo G, Zavan B. Hyaluronan Benzyl Ester as a Scaffold for Tissue Engineering. International Journal of Molecular Sciences. 2009; 10(7):2972-2985.

Chicago/Turabian Style

Vindigni, Vincenzo; Cortivo, Roberta; Iacobellis, Laura; Abatangelo, Giovanni; Zavan, Barbara. 2009. "Hyaluronan Benzyl Ester as a Scaffold for Tissue Engineering." Int. J. Mol. Sci. 10, no. 7: 2972-2985.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert