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Int. J. Mol. Sci. 2009, 10(7), 3224-3234; doi:10.3390/ijms10073224
Article

The Evaluation of the Possibilities of Using PLGA Co-Polymer and Its Composites with Carbon Fibers or Hydroxyapatite in the Bone Tissue Regeneration Process – in Vitro and in Vivo Examinations

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Received: 28 June 2009 / Revised: 14 July 2009 / Accepted: 15 July 2009 / Published: 15 July 2009
(This article belongs to the Special Issue Biocompatibility of Materials)
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Abstract

Synthetic polymers belonging to the aliphatic polyester group have become highly promising biomaterials for reconstructive medicine. The purpose of the present work is a biological evaluation of lactide-glycolide co-polymer (PLGA) and its composites with carbon fibers (PLGA+CF) or hydroxyapatite (PLGA+HA). The cytotoxicity of the evaluated materials towards hFOB 1.19 human osteoblast-like cells was assessed. Moreover, during the one-year contact of the assessed materials with living osseous tissue, the progress of bone formation was analyzed and the accompanying process of the materials’ degradation was evaluated. The materials under evaluation proved to be biocompatible.
Keywords: composites; PLGA co-polymer; carbon fibers; hydroxyapatite; human osteoblast-like cells; cytotoxicity; in vivo experiments on animals; biocompatibility composites; PLGA co-polymer; carbon fibers; hydroxyapatite; human osteoblast-like cells; cytotoxicity; in vivo experiments on animals; biocompatibility
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cieślik, M.; Mertas, A.; Morawska-Chochół, A.; Sabat, D.; Orlicki, R.; Owczarek, A.; Król, W.; Cieślik, T. The Evaluation of the Possibilities of Using PLGA Co-Polymer and Its Composites with Carbon Fibers or Hydroxyapatite in the Bone Tissue Regeneration Process – in Vitro and in Vivo Examinations. Int. J. Mol. Sci. 2009, 10, 3224-3234.

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