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Int. J. Mol. Sci. 2009, 10(7), 3224-3234; doi:10.3390/ijms10073224
Article

The Evaluation of the Possibilities of Using PLGA Co-Polymer and Its Composites with Carbon Fibers or Hydroxyapatite in the Bone Tissue Regeneration Process – in Vitro and in Vivo Examinations

1,* , 2
, 3, 4
, 1
, 5
, 2
 and 6
1 Chair and Department of Stomatological Material Science, Pl. Akademicki 17, 41 907 Bytom, Medical University of Silesia, Katowice, Poland 2 Chair and Department of Microbiology and Immunology, Jordana 19, 41 808 Zabrze, Medical University of Silesia, Katowice, Poland 3 Department of Biomaterials, Faculty of Materials Science and Ceramics, Al. Mickiewicza 30, 30 059 Cracow, AGH University of Science and Technology, Cracow, Poland 4 Department and Institute of Pathomorphology, 3maja 13-15, 41 800 Zabrze, Medical University of Silesia, Poland 5 Division of Statistics, Ostrogórska 30, 95 010 Sosnowiec, Medical University of Silesia, Katowice, Poland 6 Department and Clinic of Maxillofacial Surgery, Francuska 20/24, 40 027 Katowice, Medical University of Silesia, Katowice, Poland
* Author to whom correspondence should be addressed.
Received: 28 June 2009 / Revised: 14 July 2009 / Accepted: 15 July 2009 / Published: 15 July 2009
(This article belongs to the Special Issue Biocompatibility of Materials)
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Abstract

Synthetic polymers belonging to the aliphatic polyester group have become highly promising biomaterials for reconstructive medicine. The purpose of the present work is a biological evaluation of lactide-glycolide co-polymer (PLGA) and its composites with carbon fibers (PLGA+CF) or hydroxyapatite (PLGA+HA). The cytotoxicity of the evaluated materials towards hFOB 1.19 human osteoblast-like cells was assessed. Moreover, during the one-year contact of the assessed materials with living osseous tissue, the progress of bone formation was analyzed and the accompanying process of the materials’ degradation was evaluated. The materials under evaluation proved to be biocompatible.
Keywords: composites; PLGA co-polymer; carbon fibers; hydroxyapatite; human osteoblast-like cells; cytotoxicity; in vivo experiments on animals; biocompatibility composites; PLGA co-polymer; carbon fibers; hydroxyapatite; human osteoblast-like cells; cytotoxicity; in vivo experiments on animals; biocompatibility
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cieślik, M.; Mertas, A.; Morawska-Chochół, A.; Sabat, D.; Orlicki, R.; Owczarek, A.; Król, W.; Cieślik, T. The Evaluation of the Possibilities of Using PLGA Co-Polymer and Its Composites with Carbon Fibers or Hydroxyapatite in the Bone Tissue Regeneration Process – in Vitro and in Vivo Examinations. Int. J. Mol. Sci. 2009, 10, 3224-3234.

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