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Int. J. Mol. Sci. 2009, 10(12), 5296-5325; doi:10.3390/ijms10125296
Article

On the Physical Meaning of the Isothermal Titration Calorimetry Measurements in Calorimeters with Full Cells

1
 and 2,*
Received: 7 October 2009; in revised form: 6 November 2009 / Accepted: 8 December 2009 / Published: 9 December 2009
(This article belongs to the Special Issue Isothermal Titration Calorimetry)
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Abstract: We have performed a detailed study of the thermodynamics of the titration Process in an isothermal titration calorimeter with full cells. We show that the relationship between the enthalpy and the heat measured is better described in terms of the equation ΔH = Winj + Q (where Winj is the work necessary to carry out the titration) than in terms of ΔH = Q. Moreover, we show that the heat of interaction between two components is related to the partial enthalpy of interaction at infinite dilution of the titrant component, as well as to its partial volume of interaction at infinite dilution.
Keywords: isothermal titration calorimetry; ITC; calorimetry; thermodynamics; infinite dilution; binding; partial properties; enthalpy; heat isothermal titration calorimetry; ITC; calorimetry; thermodynamics; infinite dilution; binding; partial properties; enthalpy; heat
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Grolier, J.-P.E.; Del Río, J.M. On the Physical Meaning of the Isothermal Titration Calorimetry Measurements in Calorimeters with Full Cells. Int. J. Mol. Sci. 2009, 10, 5296-5325.

AMA Style

Grolier J-PE, Del Río JM. On the Physical Meaning of the Isothermal Titration Calorimetry Measurements in Calorimeters with Full Cells. International Journal of Molecular Sciences. 2009; 10(12):5296-5325.

Chicago/Turabian Style

Grolier, Jean-Pierre E.; Del Río, Jose Manuel. 2009. "On the Physical Meaning of the Isothermal Titration Calorimetry Measurements in Calorimeters with Full Cells." Int. J. Mol. Sci. 10, no. 12: 5296-5325.


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