Special Issue "Isothermal Titration Calorimetry"

Guest Editor
Prof. Dr. Tom L. Blundell
Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, UK
E-Mail: tom@cryst.bioc.cam.ac.uk

Guest Editor
Dr. Alan Brown
Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA Cambridge, UK
E-Mail: alan@cryst.bioc.cam.ac.uk

Dear Colleagues,

Over the past decade Isothermal Titration Calorimetry (ITC) has been one of the fastest developing biophysical techniques, no longer constrained to specialist laboratories. Usage growth can be attributed to its near universality in studying biological macromolecular interactions coupled to its ease of use, adaptability and the quality of information that can be derived from a single titration.

ITC accurately determines the binding constant (K), reaction stoichiometry (n) and the thermodynamic contributions of enthalpy (DH) and entropy (TDS) changes to free energies of binding (DG). The combination of thermodynamic and structural information has dramatically enhanced our understanding of biological interactions in solution.

In this Special Issue, authors describe and analyse some of the most exciting new applications of ITC, including the use of ITC as a practical tool in enzyme assay development, studying small molecule-protein interactions in drug discovery and dissecting thermodynamic cooperativity in multivalent systems. This issue also demonstrates the application range of ITC with reviews describing interactions involving copolymers, surfactants, lipids and nucleic acid G-quadruplexes.

Alan Brown
Tom L. Blundell
Guest Editors

Submission

All papers should be submitted to ijms@mdpi.com. To be published continuously until the deadline and papers will be listed together at the special issue website.

Submitted papers should not have been published previously, nor be under consideration for publication elsewhere. All papers are refereed through a peer-review process. A guide for authors is available on the Instructions for Authors page. The International Journal of Molecular Sciences is an international peer-reviewed monthly journal published by MDPI.

Open Access publication fees are 800 CHF per paper. English correction fees and/or formatting fees (250 CHF) will be added in certain cases (1050 CHF per paper for those papers that require extensive additional formatting and/or English corrections).

• isothermal titration calorimetry
• biocalorimetry
• microcalorimetry
• thermodynamic parameters of biochemical interactions
• binding affinity, enthalpy changes and binding stoichiometry measurements
• Gibbs energy
• entropy change