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Int. J. Mol. Sci. 2009, 10(11), 4742-4753; doi:10.3390/ijms10114742

Antinociceptive and Anti-Inflammatory Effects of Ethanolic Extracts of Glycine max (L.) Merr and Rhynchosia nulubilis Seeds

1
Korea Food Research Institute, Seongnam, Kyonggi, 463-746, Korea
2
Department of Biomedical Science, CHA University, Seongnam, Kyonggi, 463-836, Korea
3
Pohang Center for Evaluation of Biomaterials, Pohang 790-834, Korea
*
Authors to whom correspondence should be addressed.
Received: 11 October 2009 / Revised: 2 November 2009 / Accepted: 4 November 2009 / Published: 4 November 2009
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The aim of this study was to assess the in vivo potential of ethanolic extracts of Glycine max (L.) Merr. (SoRiTae) and Rhynchosia nulubilis (Yak-Kong) seeds as natural anti-nociceptive and anti-inflammatory agents. To assess the anti-nociceptive and antiinflammatory potential, the ethanolic extracts of SoRiTae and Yak-Kong seeds were tested in arachidonic acid-induced ear edema, carrageenan induced paw edema, formalin-induced licking time, acetic acid induced writhing and hot plate-induced thermal stimulation in mice. The administration of ethanolic extracts of SoRiTae and Yak-Kong seeds evoked a significant effect of anti-nociceptive and anti-inflammatory activities as compared to standards aminopyrine and indomethacin. The ear edema, paw edema, paw licking time, pain and writhes in mice were significantly reduced (p < 0.05) as compared to the control. The results obtained in this study indicate that both SoRiTae and Yak-Kong soybeans possesses potential anti-nociceptive and anti-inflammatory activities.
Keywords: Glycine max; Rhynchosia nulubilis; anti-inflammatory activity; anti-nociceptive activity Glycine max; Rhynchosia nulubilis; anti-inflammatory activity; anti-nociceptive activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Yim, J.H.; Lee, O.-H.; Choi, U.-K.; Kim, Y.-C. Antinociceptive and Anti-Inflammatory Effects of Ethanolic Extracts of Glycine max (L.) Merr and Rhynchosia nulubilis Seeds. Int. J. Mol. Sci. 2009, 10, 4742-4753.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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