Int. J. Mol. Sci. 2009, 10(11), 4742-4753; doi:10.3390/ijms10114742
Article

Antinociceptive and Anti-Inflammatory Effects of Ethanolic Extracts of Glycine max (L.) Merr and Rhynchosia nulubilis Seeds

1 Korea Food Research Institute, Seongnam, Kyonggi, 463-746, Korea 2 Department of Biomedical Science, CHA University, Seongnam, Kyonggi, 463-836, Korea 3 Pohang Center for Evaluation of Biomaterials, Pohang 790-834, Korea
* Authors to whom correspondence should be addressed.
Received: 11 October 2009; in revised form: 2 November 2009 / Accepted: 4 November 2009 / Published: 4 November 2009
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: The aim of this study was to assess the in vivo potential of ethanolic extracts of Glycine max (L.) Merr. (SoRiTae) and Rhynchosia nulubilis (Yak-Kong) seeds as natural anti-nociceptive and anti-inflammatory agents. To assess the anti-nociceptive and antiinflammatory potential, the ethanolic extracts of SoRiTae and Yak-Kong seeds were tested in arachidonic acid-induced ear edema, carrageenan induced paw edema, formalin-induced licking time, acetic acid induced writhing and hot plate-induced thermal stimulation in mice. The administration of ethanolic extracts of SoRiTae and Yak-Kong seeds evoked a significant effect of anti-nociceptive and anti-inflammatory activities as compared to standards aminopyrine and indomethacin. The ear edema, paw edema, paw licking time, pain and writhes in mice were significantly reduced (p < 0.05) as compared to the control. The results obtained in this study indicate that both SoRiTae and Yak-Kong soybeans possesses potential anti-nociceptive and anti-inflammatory activities.
Keywords: Glycine max; Rhynchosia nulubilis; anti-inflammatory activity; anti-nociceptive activity

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MDPI and ACS Style

Yim, J.H.; Lee, O.-H.; Choi, U.-K.; Kim, Y.-C. Antinociceptive and Anti-Inflammatory Effects of Ethanolic Extracts of Glycine max (L.) Merr and Rhynchosia nulubilis Seeds. Int. J. Mol. Sci. 2009, 10, 4742-4753.

AMA Style

Yim JH, Lee O-H, Choi U-K, Kim Y-C. Antinociceptive and Anti-Inflammatory Effects of Ethanolic Extracts of Glycine max (L.) Merr and Rhynchosia nulubilis Seeds. International Journal of Molecular Sciences. 2009; 10(11):4742-4753.

Chicago/Turabian Style

Yim, Joo Hyuk; Lee, Ok-Hwan; Choi, Ung-Kyu; Kim, Young-Chan. 2009. "Antinociceptive and Anti-Inflammatory Effects of Ethanolic Extracts of Glycine max (L.) Merr and Rhynchosia nulubilis Seeds." Int. J. Mol. Sci. 10, no. 11: 4742-4753.

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