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Int. J. Mol. Sci. 2009, 10(11), 4742-4753; doi:10.3390/ijms10114742
Article

Antinociceptive and Anti-Inflammatory Effects of Ethanolic Extracts of Glycine max (L.) Merr and Rhynchosia nulubilis Seeds

1
, 2,* , 3
 and 1,*
Received: 11 October 2009; in revised form: 2 November 2009 / Accepted: 4 November 2009 / Published: 4 November 2009
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract: The aim of this study was to assess the in vivo potential of ethanolic extracts of Glycine max (L.) Merr. (SoRiTae) and Rhynchosia nulubilis (Yak-Kong) seeds as natural anti-nociceptive and anti-inflammatory agents. To assess the anti-nociceptive and antiinflammatory potential, the ethanolic extracts of SoRiTae and Yak-Kong seeds were tested in arachidonic acid-induced ear edema, carrageenan induced paw edema, formalin-induced licking time, acetic acid induced writhing and hot plate-induced thermal stimulation in mice. The administration of ethanolic extracts of SoRiTae and Yak-Kong seeds evoked a significant effect of anti-nociceptive and anti-inflammatory activities as compared to standards aminopyrine and indomethacin. The ear edema, paw edema, paw licking time, pain and writhes in mice were significantly reduced (p < 0.05) as compared to the control. The results obtained in this study indicate that both SoRiTae and Yak-Kong soybeans possesses potential anti-nociceptive and anti-inflammatory activities.
Keywords: Glycine max; Rhynchosia nulubilis; anti-inflammatory activity; anti-nociceptive activity Glycine max; Rhynchosia nulubilis; anti-inflammatory activity; anti-nociceptive activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Yim, J.H.; Lee, O.-H.; Choi, U.-K.; Kim, Y.-C. Antinociceptive and Anti-Inflammatory Effects of Ethanolic Extracts of Glycine max (L.) Merr and Rhynchosia nulubilis Seeds. Int. J. Mol. Sci. 2009, 10, 4742-4753.

AMA Style

Yim JH, Lee O-H, Choi U-K, Kim Y-C. Antinociceptive and Anti-Inflammatory Effects of Ethanolic Extracts of Glycine max (L.) Merr and Rhynchosia nulubilis Seeds. International Journal of Molecular Sciences. 2009; 10(11):4742-4753.

Chicago/Turabian Style

Yim, Joo Hyuk; Lee, Ok-Hwan; Choi, Ung-Kyu; Kim, Young-Chan. 2009. "Antinociceptive and Anti-Inflammatory Effects of Ethanolic Extracts of Glycine max (L.) Merr and Rhynchosia nulubilis Seeds." Int. J. Mol. Sci. 10, no. 11: 4742-4753.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert