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Int. J. Mol. Sci. 2009, 10(10), 4330-4341; doi:10.3390/ijms10104330
Article

Extraction of Teucrium manghuaense and Evaluation of the Bioactivity of Its Extract

1,* , 2, 3 and 1
1 Analysis and Test Center of Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China 2 Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China 3 Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Wanning 571533, China
* Author to whom correspondence should be addressed.
Received: 15 July 2009 / Revised: 9 September 2009 / Accepted: 24 September 2009 / Published: 9 October 2009
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

The ethanol extract of Teucrium manghuaense grown in Hainan province (China) was analysed by GC and GC/MS. Of the constituents 84–96% were identified on the basis of their GC retention times and their mass spectra in regard to authentic compounds. The results revealed that it contained 9-methyl-9-azabicyclo[4.2.1]nonane (7.43%), 2-methylpyrrolidine (19.42%), 3,7,11,15-tetramethyl-2-hexadecen-1-ol (10.84%), and squalene (28.55%), as major components, constituting 66.24% of the extract. The chemical characterization of the ethanol extract by GC/MS also allowed identification of 1-octen-3-one (3.41%), 2-pentyl-piperidine (2.25%), 1-(2-methyl-1-propenyl)-piperidine (4.63%), 2,2'-diethoxy-5,5'-bi-1-pyrroline (0.41%), (Z,Z,Z)-9,12,15-octadecatrieniic acid, 2,3-dihydroxypropyl ester (1.56%), vitamin E (2.95%) and stigmasterol (1.39%). Finally, the antioxidant and anti-tumor activities of the ethanol extract have been evaluated. Results show that the extract of Teucrium manghuaense leaf possesses strong DPPH-, hydroxyl radical scavenging activity and anti-tumor activity.
Keywords: Teucrium manghuaense; extraction; squalene; GC-MS; antioxidant; anti-tumor Teucrium manghuaense; extraction; squalene; GC-MS; antioxidant; anti-tumor
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Yin, G.; Zeng, H.; He, M.; Wang, M. Extraction of Teucrium manghuaense and Evaluation of the Bioactivity of Its Extract. Int. J. Mol. Sci. 2009, 10, 4330-4341.

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