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Int. J. Mol. Sci. 2009, 10(1), 221-231; doi:10.3390/ijms10010221

Structural Antitumoral Activity Relationships of Synthetic Chalcones

1 Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, El Líbano 5524, Macul, Santiago, Chile 2 Universidad Andres Bello, Departamento de Ciencias Químicas, Av. República 275, Santiago, Chile
* Author to whom correspondence should be addressed.
Received: 30 September 2008 / Revised: 31 December 2008 / Accepted: 4 January 2009 / Published: 9 January 2009
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2’-hydroxychalcones resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated reactivity indexes and the adiabatic electron affinities using the DFT method including solvent effects, suggest a structure-activity relationship between the Chalcones structure and the apoptosis in HepG2 cells. The absence of methoxy substituents in the B ring of synthetic 2’-hydroxychalcones, showed the mayor structure-activity pattern along the series.
Keywords: Antitumoral activity; DFT; structure-activity relationships Antitumoral activity; DFT; structure-activity relationships
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Echeverria, C.; Santibañez, J.F.; Donoso-Tauda, O.; Escobar, C.A.; Ramirez-Tagle, R. Structural Antitumoral Activity Relationships of Synthetic Chalcones. Int. J. Mol. Sci. 2009, 10, 221-231.

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