Int. J. Mol. Sci. 2009, 10(1), 221-231; doi:10.3390/ijms10010221

Structural Antitumoral Activity Relationships of Synthetic Chalcones

1email, 1email, 2email, 2email and 2,* email
Received: 30 September 2008; in revised form: 31 December 2008 / Accepted: 4 January 2009 / Published: 9 January 2009
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2’-hydroxychalcones resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated reactivity indexes and the adiabatic electron affinities using the DFT method including solvent effects, suggest a structure-activity relationship between the Chalcones structure and the apoptosis in HepG2 cells. The absence of methoxy substituents in the B ring of synthetic 2’-hydroxychalcones, showed the mayor structure-activity pattern along the series.
Keywords: Antitumoral activity; DFT; structure-activity relationships
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MDPI and ACS Style

Echeverria, C.; Santibañez, J.F.; Donoso-Tauda, O.; Escobar, C.A.; Ramirez-Tagle, R. Structural Antitumoral Activity Relationships of Synthetic Chalcones. Int. J. Mol. Sci. 2009, 10, 221-231.

AMA Style

Echeverria C, Santibañez JF, Donoso-Tauda O, Escobar CA, Ramirez-Tagle R. Structural Antitumoral Activity Relationships of Synthetic Chalcones. International Journal of Molecular Sciences. 2009; 10(1):221-231.

Chicago/Turabian Style

Echeverria, Cesar; Santibañez, Juan Francisco; Donoso-Tauda, Oscar; Escobar, Carlos A.; Ramirez-Tagle, Rodrigo. 2009. "Structural Antitumoral Activity Relationships of Synthetic Chalcones." Int. J. Mol. Sci. 10, no. 1: 221-231.

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