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Molecules 2004, 9(3), 178-184; doi:10.3390/90300178
Article

Biaryl Product Formation from Cross-coupling in Palladiumcatalyzed Borylation of a Boc Protected Aminobromoquinoline Compound

,  and *
Department of Chemistry, Georgia State University, 33 Gilmer St. S.E., Atlanta, GA 30303 USA
* Author to whom correspondence should be addressed.
Received: 18 February 2004 / Accepted: 20 February 2004 / Published: 28 February 2004
(This article belongs to the Special Issue Biologically Relevant Heterocyclic Compounds)
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Abstract

The palladium catalyzed borylation of a Boc protected aminobromoquinoline compound with bis(pinacolato)diboron yielded a biaryl compound, resulting from cross coupling, as the major product, instead of the intended boronate, even though no strong base was used. Such results indicate that under certain conditions and with certain substrates, cross coupling can be a major problem during borylation, leading to unintended consequences.
Keywords: Palladium-catalyzed reaction; Borylation; Cross-coupling. Palladium-catalyzed reaction; Borylation; Cross-coupling.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Fang, H.; Yan, J.; Wang, B. Biaryl Product Formation from Cross-coupling in Palladiumcatalyzed Borylation of a Boc Protected Aminobromoquinoline Compound. Molecules 2004, 9, 178-184.

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