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Molecules 2004, 9(3), 109-116; doi:10.3390/90300109
Article

Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides

1,* , 2 and 1
Received: 13 January 2004; Accepted: 20 January 2004 / Published: 28 February 2004
(This article belongs to the Special Issue Biologically Relevant Heterocyclic Compounds)
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Abstract: 2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for theirantitumor activity. The structures of these compounds were established by 1H and 13C-NMR spectroscopy. Glucoside 3b shows an in vitro IC50 value of 16.4 μM againstproliferation of the human promyelotic leukemia (HL60) cell line.
Keywords: Trifluoromethylpyrazole; glucopyranose; antitumor agents. Trifluoromethylpyrazole; glucopyranose; antitumor agents.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Abdou, I.M.; Saleh, A.M.; Zohdi, H.F. Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides. Molecules 2004, 9, 109-116.

AMA Style

Abdou IM, Saleh AM, Zohdi HF. Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides. Molecules. 2004; 9(3):109-116.

Chicago/Turabian Style

Abdou, Ibrahim M.; Saleh, Ayman M.; Zohdi, Hussein F. 2004. "Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides." Molecules 9, no. 3: 109-116.


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