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Molecules 2004, 9(3), 109-116; doi:10.3390/90300109

Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides

1,* , 2 and 1
1 Department of Chemistry, Faculty of Science, UAE University, Al-Ain P.O. Box 17551, UAE 2 Department of Biochemistry, Faculty of Medicine & Health Sciences, UAE University, Al-Ain P.O.Box 17666, UAE
* Author to whom correspondence should be addressed.
Received: 13 January 2004 / Accepted: 20 January 2004 / Published: 28 February 2004
(This article belongs to the Special Issue Biologically Relevant Heterocyclic Compounds)
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2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for theirantitumor activity. The structures of these compounds were established by 1H and 13C-NMR spectroscopy. Glucoside 3b shows an in vitro IC50 value of 16.4 μM againstproliferation of the human promyelotic leukemia (HL60) cell line.
Keywords: Trifluoromethylpyrazole; glucopyranose; antitumor agents. Trifluoromethylpyrazole; glucopyranose; antitumor agents.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Abdou, I.M.; Saleh, A.M.; Zohdi, H.F. Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides. Molecules 2004, 9, 109-116.

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