Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides

doi:10.3390/90300109

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Molecules 2004, 9(3), 109-116; doi:10.3390/90300109

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Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides

Ibrahim M. Abdou^1,* , Ayman M. Saleh² and Hussein F.. Zohdi¹

¹ Department of Chemistry, Faculty of Science, UAE University, Al-Ain P.O. Box 17551, UAE ² Department of Biochemistry, Faculty of Medicine & Health Sciences, UAE University, Al-Ain P.O.Box 17666, UAE

* Author to whom correspondence should be addressed.

Received: 13 January 2004 / Accepted: 20 January 2004 / Published: 28 February 2004

(This article belongs to the Special Issue Biologically Relevant Heterocyclic Compounds)

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Abstract: 2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for theirantitumor activity. The structures of these compounds were established by ¹H and ¹³C-NMR spectroscopy. Glucoside 3b shows an in vitro IC₅₀ value of 16.4 μM againstproliferation of the human promyelotic leukemia (HL60) cell line.

Keywords: Trifluoromethylpyrazole; glucopyranose; antitumor agents.

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MDPI and ACS Style

Abdou, I.M.; Saleh, A.M.; Zohdi, H.F. Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides. Molecules 2004, 9, 109-116.

AMA Style

Abdou IM, Saleh AM, Zohdi HF. Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides. Molecules. 2004; 9(3):109-116.

Chicago/Turabian Style

Abdou, Ibrahim M.; Saleh, Ayman M.; Zohdi, Hussein F. 2004. "Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides." Molecules 9, no. 3: 109-116.

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