Molecules 2004, 9(3), 109-116; doi:10.3390/90300109
Article

Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides

1 Department of Chemistry, Faculty of Science, UAE University, Al-Ain P.O. Box 17551, UAE 2 Department of Biochemistry, Faculty of Medicine & Health Sciences, UAE University, Al-Ain P.O.Box 17666, UAE
* Author to whom correspondence should be addressed.
Received: 13 January 2004; Accepted: 20 January 2004 / Published: 28 February 2004
(This article belongs to the Special Issue Biologically Relevant Heterocyclic Compounds)
PDF Full-text Download PDF Full-Text [169 KB, uploaded 20 June 2008 17:08 CEST]
Abstract: 2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for theirantitumor activity. The structures of these compounds were established by 1H and 13C-NMR spectroscopy. Glucoside 3b shows an in vitro IC50 value of 16.4 μM againstproliferation of the human promyelotic leukemia (HL60) cell line.
Keywords: Trifluoromethylpyrazole; glucopyranose; antitumor agents.

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Abdou, I.M.; Saleh, A.M.; Zohdi, H.F. Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides. Molecules 2004, 9, 109-116.

AMA Style

Abdou IM, Saleh AM, Zohdi HF. Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides. Molecules. 2004; 9(3):109-116.

Chicago/Turabian Style

Abdou, Ibrahim M.; Saleh, Ayman M.; Zohdi, Hussein F. 2004. "Synthesis and Antitumor Activity of 5-Trifluoromethyl-2,4- dihydropyrazol-3-one Nucleosides." Molecules 9, no. 3: 109-116.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert