Molecules 2004, 9(3), 102-108; doi:10.3390/90300102
Article

Structure-Activity Relationships for the 9-(Pyridin-2’-yl)- aminoacridines

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Received: 19 January 2004; Accepted: 25 January 2004 / Published: 28 February 2004
(This article belongs to the Special Issue Biologically Relevant Heterocyclic Compounds)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A series of 9-(pyridin-2’-yl)-aminoacridines was prepared and analyzed for their ability to change the thermal denaturation temperature of genomic calf thymus DNA. Development of a QSAR equation indicated that electron withdrawing groups on the pyridine ring promoted the interaction with double stranded DNA.
Keywords: Acridine; QSAR; pyridine; DNA.
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MDPI and ACS Style

Mosher, M.D.; Holmes, K.L.; Frost, K.S. Structure-Activity Relationships for the 9-(Pyridin-2’-yl)- aminoacridines. Molecules 2004, 9, 102-108.

AMA Style

Mosher MD, Holmes KL, Frost KS. Structure-Activity Relationships for the 9-(Pyridin-2’-yl)- aminoacridines. Molecules. 2004; 9(3):102-108.

Chicago/Turabian Style

Mosher, Michael D.; Holmes, Kristi L.; Frost, Katherine S. 2004. "Structure-Activity Relationships for the 9-(Pyridin-2’-yl)- aminoacridines." Molecules 9, no. 3: 102-108.

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