Molecules 2004, 9(3), 102-108; doi:10.3390/90300102
Article

Structure-Activity Relationships for the 9-(Pyridin-2’-yl)- aminoacridines

Department of Chemistry, University of Nebraska at Kearney, 905 W. 25th St., Kearney, Nebraska 68849-1150, USA
* Author to whom correspondence should be addressed.
Received: 19 January 2004; Accepted: 25 January 2004 / Published: 28 February 2004
(This article belongs to the Special Issue Biologically Relevant Heterocyclic Compounds)
PDF Full-text Download PDF Full-Text [159 KB, uploaded 20 June 2008 17:08 CEST]
Abstract: A series of 9-(pyridin-2’-yl)-aminoacridines was prepared and analyzed for their ability to change the thermal denaturation temperature of genomic calf thymus DNA. Development of a QSAR equation indicated that electron withdrawing groups on the pyridine ring promoted the interaction with double stranded DNA.
Keywords: Acridine; QSAR; pyridine; DNA.

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Mosher, M.D.; Holmes, K.L.; Frost, K.S. Structure-Activity Relationships for the 9-(Pyridin-2’-yl)- aminoacridines. Molecules 2004, 9, 102-108.

AMA Style

Mosher MD, Holmes KL, Frost KS. Structure-Activity Relationships for the 9-(Pyridin-2’-yl)- aminoacridines. Molecules. 2004; 9(3):102-108.

Chicago/Turabian Style

Mosher, Michael D.; Holmes, Kristi L.; Frost, Katherine S. 2004. "Structure-Activity Relationships for the 9-(Pyridin-2’-yl)- aminoacridines." Molecules 9, no. 3: 102-108.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert