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Molecules 2004, 9(3), 102-108; doi:10.3390/90300102

Structure-Activity Relationships for the 9-(Pyridin-2’-yl)- aminoacridines

* ,  and
Received: 19 January 2004; Accepted: 25 January 2004 / Published: 28 February 2004
(This article belongs to the Special Issue Biologically Relevant Heterocyclic Compounds)
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Abstract: A series of 9-(pyridin-2’-yl)-aminoacridines was prepared and analyzed for their ability to change the thermal denaturation temperature of genomic calf thymus DNA. Development of a QSAR equation indicated that electron withdrawing groups on the pyridine ring promoted the interaction with double stranded DNA.
Keywords: Acridine; QSAR; pyridine; DNA. Acridine; QSAR; pyridine; DNA.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Mosher, M.D.; Holmes, K.L.; Frost, K.S. Structure-Activity Relationships for the 9-(Pyridin-2’-yl)- aminoacridines. Molecules 2004, 9, 102-108.

AMA Style

Mosher MD, Holmes KL, Frost KS. Structure-Activity Relationships for the 9-(Pyridin-2’-yl)- aminoacridines. Molecules. 2004; 9(3):102-108.

Chicago/Turabian Style

Mosher, Michael D.; Holmes, Kristi L.; Frost, Katherine S. 2004. "Structure-Activity Relationships for the 9-(Pyridin-2’-yl)- aminoacridines." Molecules 9, no. 3: 102-108.

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