Next Article in Journal
Asymmetric Synthesis and Antimicrobial Activity of Some New Mono and Bicyclic β-Lactams
Previous Article in Journal
Synthesis and Biological Activities of Novel Triazole Compounds Containing 1,3-Dioxolane Rings
Article Menu

Export Article

Open AccessArticle
Molecules 2004, 9(11), 922-938; doi:10.3390/91100922

Quantum Chemical and Experimental Studies on the Mechanism of Alkylation of β-Dicarbonyl Compounds. The Synthesis of Five and Six Membered Heterocyclic Spiro Derivatives

1
Baku St. University, Faculty of Chemistry, Department of Organic Chemistry, Baku, Azerbaijan
2
Osmangazi University, Faculty of Arts and Sciences, Chemistry Department, 26040 Eskişehir, Turkey
3
Anadolu University, Faculty of Sciences, Chemistry Department, 26470 Eskişehir, Turkey
4
Baku St. University, Faculty of Chemistry, Department of Analytical Chemistry, Baku, Azerbaijan
*
Author to whom correspondence should be addressed.
Received: 5 March 2004 / Accepted: 24 June 2004 / Published: 30 November 2004
View Full-Text   |   Download PDF [247 KB, uploaded 18 June 2014]   |  

Abstract

The alkylation of β-dicarbonyl compounds in a K2CO3/DMSO system wasfound to afford O- and C-alkylated derivatives, depending on the type of the β-dicarbonylcompound involved. The alkyl derivatives obtained were used in the synthesis of some newspiro barbituric acid derivatives. Quantum chemical calculations were carried out toelucidate the reaction mechanisms for some typical synthesis. View Full-Text
Keywords: Alkylation of β-dicarbonyl compounds; spiro derivatives of barbituric acid; 2-chloro-1-(2- chloroethoxy)ethane; theoretical studies. Alkylation of β-dicarbonyl compounds; spiro derivatives of barbituric acid; 2-chloro-1-(2- chloroethoxy)ethane; theoretical studies.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Sadikov, N.; Nasibov, S.; Ogretir, C.; Berber, H.; Hüseyinli, A. Quantum Chemical and Experimental Studies on the Mechanism of Alkylation of β-Dicarbonyl Compounds. The Synthesis of Five and Six Membered Heterocyclic Spiro Derivatives. Molecules 2004, 9, 922-938.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top