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Molecules 2003, 8(8), 642-648; doi:10.3390/80800642
Article

Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines

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Received: 21 February 2003; in revised form: 28 July 2003 / Accepted: 30 July 2003 / Published: 31 July 2003
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Abstract: Condensation of 2-acetylnaphthalene with benzaldehydes under microwave irradiation affords chalcones which undergo facile and clean cyclizations with hydrazines RNHNH2 (R= H, Ph, Ac) to afford 3,5-arylated 2-pyrazolines in quantitative yields, also under microwave irradiation and in the presence of dry AcOH as cyclizing agent. The results obtained indicate that, unlike classical heating, microwave irradiation results in higher yields, shorter reaction times (2-12 min.) and cleaner reactions.
Keywords: Microwave irradiation; chalcones; 3; 5-arylated-2-pyrazolines; pyrazolines; heterocyclic synthesis Microwave irradiation; chalcones; 3; 5-arylated-2-pyrazolines; pyrazolines; heterocyclic synthesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Azarifar, D.; Ghasemnejad, H. Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines. Molecules 2003, 8, 642-648.

AMA Style

Azarifar D, Ghasemnejad H. Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines. Molecules. 2003; 8(8):642-648.

Chicago/Turabian Style

Azarifar, Davood; Ghasemnejad, Hassan. 2003. "Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines." Molecules 8, no. 8: 642-648.


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