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Molecules 2003, 8(8), 642-648; doi:10.3390/80800642

Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines

Department of Chemistry, Faculty of Science, Bu Ali- Sina University, Zip Code 65174, Hamadan, Iran
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Author to whom correspondence should be addressed.
Received: 21 February 2003 / Revised: 28 July 2003 / Accepted: 30 July 2003 / Published: 31 July 2003
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Abstract

Condensation of 2-acetylnaphthalene with benzaldehydes under microwave irradiation affords chalcones which undergo facile and clean cyclizations with hydrazines RNHNH2 (R= H, Ph, Ac) to afford 3,5-arylated 2-pyrazolines in quantitative yields, also under microwave irradiation and in the presence of dry AcOH as cyclizing agent. The results obtained indicate that, unlike classical heating, microwave irradiation results in higher yields, shorter reaction times (2-12 min.) and cleaner reactions.
Keywords: Microwave irradiation; chalcones; 3; 5-arylated-2-pyrazolines; pyrazolines; heterocyclic synthesis Microwave irradiation; chalcones; 3; 5-arylated-2-pyrazolines; pyrazolines; heterocyclic synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Azarifar, D.; Ghasemnejad, H. Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines. Molecules 2003, 8, 642-648.

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